Description: Homo sapiens seizure threshold 2 homolog (mouse) (SZT2), mRNA. RefSeq Summary (NM_015284): The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignment to same-species transcripts and to orthologous mouse transcript (NM_198170.3). The encoded protein is supported by similar sized ortholog in mouse (NP_937813.3), and model proteins in bovine (XP_613325.4), rat (XP_001069457.2) and rabbit (XP_002715736.1). Transcript (Including UTRs) Position: hg19 chr1:43,855,556-43,919,918 Size: 64,363 Total Exon Count: 71 Strand: + Coding Region Position: hg19 chr1:43,855,640-43,916,151 Size: 60,512 Coding Exon Count: 71
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q5T011-5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
