Human Gene TMEM185A (uc011mxr.1)
  Description: Homo sapiens transmembrane protein 185A (TMEM185A), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:148,850,567-148,853,774 Size: 3,208 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chrX:148,850,585-148,853,029 Size: 2,445 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:148,850,567-148,853,774)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldEnsembl
Entrez GeneExonPrimerGeneCardsHGNCLynxMalacards
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: H0YAP3_HUMAN
DESCRIPTION: SubName: Full=Transmembrane protein 185A; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM185A
Diseases sorted by gene-association score: fraxf syndrome* (350)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.73 RPKM in Ovary
Total median expression: 42.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.1018-0.117 Picture PostScript Text
3' UTR -274.60745-0.369 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019396 - TM_Fragile-X-F-assoc

Pfam Domains:
PF10269 - Transmembrane Fragile-X-F protein

ModBase Predicted Comparative 3D Structure on H0YAP3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK128688 - Homo sapiens cDNA FLJ46855 fis, clone UTERU3010029, highly similar to Protein FAM11A.
AF353675 - Homo sapiens unknown mRNA.
BC013793 - Homo sapiens transmembrane protein 185A, mRNA (cDNA clone IMAGE:4214132), complete cds.
CU680682 - Synthetic construct Homo sapiens gateway clone IMAGE:100017962 5' read TMEM185A mRNA.
KJ904916 - Synthetic construct Homo sapiens clone ccsbBroadEn_14310 TMEM185A gene, encodes complete protein.
LF380584 - JP 2014500723-A/188087: Polycomb-Associated Non-Coding RNAs.
LF380583 - JP 2014500723-A/188086: Polycomb-Associated Non-Coding RNAs.
JD444621 - Sequence 425645 from Patent EP1572962.
JD215255 - Sequence 196279 from Patent EP1572962.
JD143631 - Sequence 124655 from Patent EP1572962.
JD253472 - Sequence 234496 from Patent EP1572962.
JD390175 - Sequence 371199 from Patent EP1572962.
JD550808 - Sequence 531832 from Patent EP1572962.
JD199124 - Sequence 180148 from Patent EP1572962.
JD172925 - Sequence 153949 from Patent EP1572962.
JD134737 - Sequence 115761 from Patent EP1572962.
JD531965 - Sequence 512989 from Patent EP1572962.
JD144378 - Sequence 125402 from Patent EP1572962.
JD026404 - Sequence 7428 from Patent EP1572962.
JD029019 - Sequence 10043 from Patent EP1572962.
JD267874 - Sequence 248898 from Patent EP1572962.
JD028314 - Sequence 9338 from Patent EP1572962.
JD025044 - Sequence 6068 from Patent EP1572962.
JD419989 - Sequence 401013 from Patent EP1572962.
JD028726 - Sequence 9750 from Patent EP1572962.
LF380582 - JP 2014500723-A/188085: Polycomb-Associated Non-Coding RNAs.
JD504449 - Sequence 485473 from Patent EP1572962.
JD280716 - Sequence 261740 from Patent EP1572962.
MA616161 - JP 2018138019-A/188087: Polycomb-Associated Non-Coding RNAs.
MA616160 - JP 2018138019-A/188086: Polycomb-Associated Non-Coding RNAs.
MA616159 - JP 2018138019-A/188085: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CU680683, H0YAP3, H0YAP3_HUMAN, NM_001174092, NP_001167563
UCSC ID: uc011mxr.1
Representative RNA: CU680683
Protein: H0YAP3

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: CU680683.1
exon count: 3CDS single in 3' UTR: no RNA size: 1032
ORF size: 519CDS single in intron: no Alignment % ID: 99.61
txCdsPredict score: 1138.00frame shift in genome: no % Coverage: 50.29
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.