Human Gene TMEM185A (uc011mxr.1)
Description: Homo sapiens transmembrane protein 185A (TMEM185A), transcript variant 2, mRNA.
Transcript (Including UTRs)
Position: hg19 chrX:148,850,567-148,853,774 Size: 3,208 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chrX:148,850,585-148,853,029 Size: 2,445 Coding Exon Count: 3
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: H0YAP3_HUMAN
DESCRIPTION: SubName: Full=Transmembrane protein 185A; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: TMEM185A
Diseases sorted by gene-association score: fraxf syndrome * (350)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR019396 - TM_Fragile-X-F-assoc
Pfam Domains: PF10269 - Transmembrane Fragile-X-F protein
ModBase Predicted Comparative 3D Structure on H0YAP3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK128688 - Homo sapiens cDNA FLJ46855 fis, clone UTERU3010029, highly similar to Protein FAM11A.AF353675 - Homo sapiens unknown mRNA.BC013793 - Homo sapiens transmembrane protein 185A, mRNA (cDNA clone IMAGE:4214132), complete cds.CU680682 - Synthetic construct Homo sapiens gateway clone IMAGE:100017962 5' read TMEM185A mRNA.KJ904916 - Synthetic construct Homo sapiens clone ccsbBroadEn_14310 TMEM185A gene, encodes complete protein.LF380584 - JP 2014500723-A/188087: Polycomb-Associated Non-Coding RNAs.LF380583 - JP 2014500723-A/188086: Polycomb-Associated Non-Coding RNAs.JD444621 - Sequence 425645 from Patent EP1572962.JD215255 - Sequence 196279 from Patent EP1572962.JD143631 - Sequence 124655 from Patent EP1572962.JD253472 - Sequence 234496 from Patent EP1572962.JD390175 - Sequence 371199 from Patent EP1572962.JD550808 - Sequence 531832 from Patent EP1572962.JD199124 - Sequence 180148 from Patent EP1572962.JD172925 - Sequence 153949 from Patent EP1572962.JD134737 - Sequence 115761 from Patent EP1572962.JD531965 - Sequence 512989 from Patent EP1572962.JD144378 - Sequence 125402 from Patent EP1572962.JD026404 - Sequence 7428 from Patent EP1572962.JD029019 - Sequence 10043 from Patent EP1572962.JD267874 - Sequence 248898 from Patent EP1572962.JD028314 - Sequence 9338 from Patent EP1572962.JD025044 - Sequence 6068 from Patent EP1572962.JD419989 - Sequence 401013 from Patent EP1572962.JD028726 - Sequence 9750 from Patent EP1572962.LF380582 - JP 2014500723-A/188085: Polycomb-Associated Non-Coding RNAs.JD504449 - Sequence 485473 from Patent EP1572962.JD280716 - Sequence 261740 from Patent EP1572962.MA616161 - JP 2018138019-A/188087: Polycomb-Associated Non-Coding RNAs.MA616160 - JP 2018138019-A/188086: Polycomb-Associated Non-Coding RNAs.MA616159 - JP 2018138019-A/188085: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: CU680683, H0YAP3, H0YAP3_HUMAN, NM_001174092, NP_001167563UCSC ID: uc011mxr.1Representative RNA: CU680683
Protein: H0YAP3
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
CU680683.1
exon count:
3 CDS single in 3' UTR:
no
RNA size:
1032
ORF size:
519 CDS single in intron:
no
Alignment % ID:
99.61
txCdsPredict score:
1138.00 frame shift in genome:
no
% Coverage:
50.29
has start codon:
yes
stop codon in genome:
no
# of Alignments:
2
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.