Bone Density Douglas P Kiel et al. BMC medical genetics 2007, Genome-wide association with bone mass and geometry in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903296]
The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis.
Carotid Artery Diseases Christopher J O'Donnell et al. BMC medical genetics 2007, Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903303]
The results from this GWAS generate hypotheses regarding several SNPs that may be associated with SCA phenotypes in multiple arterial beds. Given the number of tests conducted, subsequent independent replication in a staged approach is essential to identify genetic variants that may be implicated in atherosclerosis.
CD40 Ligand Emelia J Benjamin et al. BMC medical genetics 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903293]
The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5TGJ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
HM005397 - Homo sapiens clone HTL-T-84 testicular tissue protein Li 84 mRNA, complete cds. AK302110 - Homo sapiens cDNA FLJ50911 complete cds, moderately similar to Homo sapiens hepatoma derived growth factor-like 1 (HDGFL1), mRNA. AK056824 - Homo sapiens cDNA FLJ32262 fis, clone PROST1000362, moderately similar to HEPATOMA-DERIVED GROWTH FACTOR. BC172324 - Synthetic construct Homo sapiens clone IMAGE:100069018, MGC:199029 hepatoma derived growth factor-like 1 (HDGFL1) mRNA, encodes complete protein. DQ584678 - Homo sapiens piRNA piR-51790, complete sequence. JD137638 - Sequence 118662 from Patent EP1572962. JD229293 - Sequence 210317 from Patent EP1572962. JD360696 - Sequence 341720 from Patent EP1572962. JD037497 - Sequence 18521 from Patent EP1572962. JD204099 - Sequence 185123 from Patent EP1572962. JD104678 - Sequence 85702 from Patent EP1572962. JD210209 - Sequence 191233 from Patent EP1572962. JD189540 - Sequence 170564 from Patent EP1572962. JD133947 - Sequence 114971 from Patent EP1572962. MP015277 - Sequence 480 from Patent WO2019016252.
US Server
