Description: Homo sapiens serine/arginine repetitive matrix 4 (SRRM4), mRNA. RefSeq Summary (NM_194286): SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr12:119,419,300-119,600,856 Size: 181,557 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr12:119,419,688-119,594,603 Size: 174,916 Coding Exon Count: 13
ID:SRRM4_HUMAN DESCRIPTION: RecName: Full=Serine/arginine repetitive matrix protein 4; AltName: Full=Medulloblastoma antigen MU-MB-2.76; AltName: Full=Neural-specific serine/arginine repetitive splicing factor of 100 kDa; Short=Neural-specific SR-related protein of 100 kDa; Short=nSR100; FUNCTION: Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum. PTM: Phosphorylated (By similarity). SIMILARITY: Belongs to the nSR100 family. SEQUENCE CAUTION: Sequence=BAB47482.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF15230 - Serine/arginine repetitive matrix protein C-terminus
ModBase Predicted Comparative 3D Structure on A7MD48
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000381 regulation of alternative mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0007399 nervous system development GO:0007605 sensory perception of sound GO:0008380 RNA splicing GO:0030154 cell differentiation GO:0043484 regulation of RNA splicing
US Server
