Description: Homo sapiens heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (HNRNPD), transcript variant 1, mRNA. RefSeq Summary (NM_031370): This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr4:83,274,467-83,295,149 Size: 20,683 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr4:83,276,487-83,294,831 Size: 18,345 Coding Exon Count: 8
ID:HNRPD_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein D0; Short=hnRNP D0; AltName: Full=AU-rich element RNA-binding protein 1; FUNCTION: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. SUBUNIT: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. Interacts with GTPBP1. INTERACTION: Q04637:EIF4G1; NbExp=3; IntAct=EBI-432545, EBI-73711; Q9Y6M1:IGF2BP2; NbExp=4; IntAct=EBI-432545, EBI-1024419; Q9BYZ2:LDHAL6B; NbExp=2; IntAct=EBI-299674, EBI-1108377; P11940:PABPC1; NbExp=2; IntAct=EBI-432545, EBI-81531; P31947:SFN; NbExp=7; IntAct=EBI-432545, EBI-476295; O60506:SYNCRIP; NbExp=3; IntAct=EBI-432545, EBI-1024357; P67809:YBX1; NbExp=3; IntAct=EBI-432545, EBI-354065; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. PTM: Arg-345 is dimethylated, probably to asymmetric dimethylarginine. PTM: Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity). SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=AAA35781.1; Type=Frameshift; Positions=45, 59, 355; Sequence=AAA35781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=CAA27544.1; Type=Miscellaneous discrepancy; Note=Several sequence conflicts;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14103
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ891372 - Synthetic construct Homo sapiens clone ccsbBroadEn_00766 HNRNPD gene, encodes complete protein. KJ905781 - Synthetic construct Homo sapiens clone ccsbBroadEn_15451 HNRNPD gene, encodes complete protein. AF039575 - Homo sapiens heterogeneous nuclear ribonucleoprotein D0B mRNA, partial cds. JD094515 - Sequence 75539 from Patent EP1572962. JD046631 - Sequence 27655 from Patent EP1572962. JD491402 - Sequence 472426 from Patent EP1572962. JD025612 - Sequence 6636 from Patent EP1572962. AL832723 - Homo sapiens mRNA; cDNA DKFZp313H039 (from clone DKFZp313H039). BC002401 - Homo sapiens heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), mRNA (cDNA clone MGC:8503 IMAGE:2822230), complete cds. BC023977 - Homo sapiens heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), mRNA (cDNA clone MGC:2158 IMAGE:2961272), complete cds. BC026015 - Homo sapiens heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), mRNA (cDNA clone MGC:3882 IMAGE:2961272), complete cds. D55673 - Homo sapiens mRNA for heterogeneous nuclear ribonucleoprotein D (hnRNP D), partial cds, clone cDx8. D55671 - Homo sapiens mRNA for heterogeneous nuclear ribonucleoprotein D (hnRNP D), partial cds, clone cDx4. D55674 - Homo sapiens mRNA for heterogeneous nuclear ribonucleoprotein D (hnRNP D), complete cds, clone cDx9. D55672 - Homo sapiens mRNA for heterogeneous nuclear ribonucleoprotein D (hnRNP D), complete cds, clone cDx7. JD032977 - Sequence 14001 from Patent EP1572962. JD080607 - Sequence 61631 from Patent EP1572962. JD124009 - Sequence 105033 from Patent EP1572962. JD166843 - Sequence 147867 from Patent EP1572962. JD350884 - Sequence 331908 from Patent EP1572962. M94630 - Homo sapiens DNA-binding protein mRNA, complete cds. AK057836 - Homo sapiens cDNA FLJ25107 fis, clone CBR01496, highly similar to Human mRNA for heterogeneous nuclear ribonucleoprotein D (hnRNP D). AK300149 - Homo sapiens cDNA FLJ54150 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein D0. JD357813 - Sequence 338837 from Patent EP1572962. AK292707 - Homo sapiens cDNA FLJ76462 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (HNRPD), transcript variant 2, mRNA. AK303552 - Homo sapiens cDNA FLJ61020 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein D0. JD313690 - Sequence 294714 from Patent EP1572962. DQ892240 - Synthetic construct clone IMAGE:100004870; FLH184421.01X; RZPDo839F10144D heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (HNRPD) gene, encodes complete protein. DQ895440 - Synthetic construct Homo sapiens clone IMAGE:100009900; FLH184417.01L; RZPDo839F10143D heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (HNRPD) gene, encodes complete protein. AB463729 - Synthetic construct DNA, clone: pF1KB8275, Homo sapiens HNRPD gene for heterogeneous nuclear ribonucleoprotein D, without stop codon, in Flexi system. X03910 - Human mRNA for hnRNP C protein cross-reacting with C1 and C2 hnRNP core proteins. JD462440 - Sequence 443464 from Patent EP1572962. JD555131 - Sequence 536155 from Patent EP1572962. JD107060 - Sequence 88084 from Patent EP1572962. JD404564 - Sequence 385588 from Patent EP1572962. JD477847 - Sequence 458871 from Patent EP1572962. JD138132 - Sequence 119156 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q14103 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing R-HSA-450434 AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA R-HSA-450551 AUF1 binds translation and heat shock proteins R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-8953854 Metabolism of RNA R-HSA-450434 AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA R-HSA-450551 AUF1 binds translation and heat shock proteins R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-8953854 Metabolism of RNA
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