Description: Homo sapiens basic helix-loop-helix domain containing, class B, 9 (BHLHB9), transcript variant 8, mRNA. RefSeq Summary (NM_001142530): This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chrX:102,000,907-102,007,369 Size: 6,463 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chrX:102,003,924-102,005,567 Size: 1,644 Coding Exon Count: 1
ID:BHLH9_HUMAN DESCRIPTION: RecName: Full=Protein BHLHb9; Short=bHLHb9; AltName: Full=Transcription regulator of 60 kDa; Short=p60TRP; FUNCTION: May play a role in the control of cellular aging and survival. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly cytoplasmic, and nuclear at lower level. TISSUE SPECIFICITY: Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease. INDUCTION: Down-regulated in colon cancer cells, due to CpG hypermethylation of its promoter. SIMILARITY: Belongs to the GPRASP family. CAUTION: Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool. SEQUENCE CAUTION: Sequence=BAB21792.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6PI77
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
