Description: Homo sapiens WD repeat domain 11 (WDR11), mRNA. RefSeq Summary (NM_018117): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr10:122,610,687-122,669,038 Size: 58,352 Total Exon Count: 29 Strand: + Coding Region Position: hg19 chr10:122,610,933-122,668,225 Size: 57,293 Coding Exon Count: 29
ID:WDR11_HUMAN DESCRIPTION: RecName: Full=WD repeat-containing protein 11; AltName: Full=Bromodomain and WD repeat-containing protein 2; AltName: Full=WD repeat-containing protein 15; SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Ubiquitous. DISEASE: Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with ZNF320. SIMILARITY: Contains 9 WD repeats. SEQUENCE CAUTION: Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): WDR11 CDC HuGE Published Literature: WDR11 Positive Disease Associations: Asthma
, Coronary Disease Related Studies:
Asthma Medea Imboden et al. The Journal of allergy and clinical immunology 2012, Genome-wide association study of lung function decline in adults with and without asthma., The Journal of allergy and clinical immunology.
[PubMed 22424883]
Genetic heterogeneity of lung function might be extensive. Our results suggest that genetic determinants of longitudinal and cross-sectional lung function differ and vary by asthma status.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZH6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
