Description: Homo sapiens dual specificity phosphatase 12 (DUSP12), mRNA. RefSeq Summary (NM_007240): The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:161,719,581-161,726,952 Size: 7,372 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr1:161,719,592-161,726,737 Size: 7,146 Coding Exon Count: 6
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DUSP12 CDC HuGE Published Literature: DUSP12 Positive Disease Associations: diabetes, type 2
, Neuroblastoma Related Studies:
diabetes, type 2 Das, S. K. et al. 2006, Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes, Diabetes 2006 55(9) 2631-9.
[PubMed 16936214]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52799 - (Phosphotyrosine protein) phosphatases II
ModBase Predicted Comparative 3D Structure on Q9UNI6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
