ID:SARM1_HUMAN DESCRIPTION: RecName: Full=Sterile alpha and TIR motif-containing protein 1; AltName: Full=Sterile alpha and Armadillo repeat protein; AltName: Full=Sterile alpha motif domain-containing protein 2; Short=SAM domain-containing protein 2; AltName: Full=Tir-1 homolog; FUNCTION: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. SUBUNIT: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Predominantly expressed in kidney and liver. Expressed at lower level in placenta. SIMILARITY: Contains 2 SAM (sterile alpha motif) domains. SIMILARITY: Contains 1 TIR domain. CAUTION: Was initially (PubMed:11386760) reported to contain ARM repeats. Such repeats are however not predicted by any detection method.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00536 - SAM domain (Sterile alpha motif) PF07647 - SAM domain (Sterile alpha motif) PF13676 - TIR domain
SCOP Domains: 48371 - ARM repeat 47769 - SAM/Pointed domain 52200 - Toll/Interleukin receptor TIR domain
ModBase Predicted Comparative 3D Structure on Q6SZW1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0007165 signal transduction GO:0007399 nervous system development GO:0009749 response to glucose GO:0030154 cell differentiation GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0042981 regulation of apoptotic process GO:0045087 innate immune response GO:0048814 regulation of dendrite morphogenesis GO:1901214 regulation of neuron death
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