Description: Homo sapiens mitochondrial ribosome-associated GTPase 2 (MTG2), mRNA. RefSeq Summary (NM_015666): Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr20:60,758,081-60,777,810 Size: 19,730 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr20:60,768,477-60,776,133 Size: 7,657 Coding Exon Count: 6
ID:GTPB5_HUMAN DESCRIPTION: RecName: Full=GTP-binding protein 5; AltName: Full=Protein obg homolog 1; Short=ObgH1; FUNCTION: Involved in the ribosome maturation process. Plays a role of GTPase in vitro. When missing, mitochondria elongation and abnormal nuclear morphology are observed. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the GTP1/OBG family. SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain. SEQUENCE CAUTION: Sequence=BAA91783.1; Type=Erroneous termination; Positions=402; Note=Translated as Gln;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00025 - ADP-ribosylation factor family PF01018 - GTP1/OBG PF01926 - 50S ribosome-binding GTPase PF02421 - Ferrous iron transport protein B
ModBase Predicted Comparative 3D Structure on Q9H4K7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006417 regulation of translation GO:0042254 ribosome biogenesis GO:0044065 regulation of respiratory system process GO:0070129 regulation of mitochondrial translation
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