Human Gene BRI3BP (uc001uha.1)
  Description: Homo sapiens BRI3 binding protein (BRI3BP), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:125,478,194-125,510,349 Size: 32,156 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr12:125,478,337-125,509,976 Size: 31,640 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:125,478,194-125,510,349)mRNA (may differ from genome)Protein (251 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BRI3B_HUMAN
DESCRIPTION: RecName: Full=BRI3-binding protein; Short=I3-binding protein; AltName: Full=Cervical cancer 1 proto-oncogene-binding protein KG19; AltName: Full=HCCRBP-1;
FUNCTION: Involved in tumorigenesis and may function by stabilizing p53/TP53.
SUBUNIT: Interacts with LETMD1.
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein (Probable).
TISSUE SPECIFICITY: Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas.
SEQUENCE CAUTION: Sequence=AAL33003.2; Type=Frameshift; Positions=43, 47, 59;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.60 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 150.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.00143-0.524 Picture PostScript Text
3' UTR -91.00373-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14965 - Negative regulator of p53/TP53

ModBase Predicted Comparative 3D Structure on Q8WY22
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF384028 - JP 2014500723-A/191531: Polycomb-Associated Non-Coding RNAs.
JD186850 - Sequence 167874 from Patent EP1572962.
BC034525 - Homo sapiens BRI3 binding protein, mRNA (cDNA clone MGC:24938 IMAGE:4778946), complete cds.
AF284094 - Homo sapiens I3 binding protein (BRI3BP) mRNA, complete cds.
AF283671 - Homo sapiens cervical cancer 1 proto-oncogene-binding protein KG19 (KG19) mRNA, complete cds.
AF441865 - Homo sapiens cervical cancer oncogene binding protein mRNA, complete cds.
AK055703 - Homo sapiens cDNA FLJ31141 fis, clone IMR322001245.
JD285753 - Sequence 266777 from Patent EP1572962.
JD462131 - Sequence 443155 from Patent EP1572962.
JD338388 - Sequence 319412 from Patent EP1572962.
JD053156 - Sequence 34180 from Patent EP1572962.
JD041027 - Sequence 22051 from Patent EP1572962.
MA619605 - JP 2018138019-A/191531: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BRI3B_HUMAN, KG19, NM_080626, NP_542193, Q8WY22, Q8WY23
UCSC ID: uc001uha.1
RefSeq Accession: NM_080626
Protein: Q8WY22 (aka BRI3B_HUMAN)
CCDS: CCDS9262.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_080626.5
exon count: 3CDS single in 3' UTR: no RNA size: 1272
ORF size: 756CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1677.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.