ID:TOE1_HUMAN DESCRIPTION: RecName: Full=Target of EGR1 protein 1; FUNCTION: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles. SIMILARITY: Belongs to the CAF1 family. SIMILARITY: Contains 1 C3H1-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96GM8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AY169960 - Homo sapiens target of Egr1 protein (TOE1) mRNA, complete cds. JD429110 - Sequence 410134 from Patent EP1572962. JD425521 - Sequence 406545 from Patent EP1572962. JD532664 - Sequence 513688 from Patent EP1572962. JD439814 - Sequence 420838 from Patent EP1572962. JD227999 - Sequence 209023 from Patent EP1572962. JD379319 - Sequence 360343 from Patent EP1572962. JD202088 - Sequence 183112 from Patent EP1572962. AK293704 - Homo sapiens cDNA FLJ59313 complete cds, highly similar to Homo sapiens target of EGR1, member 1 (nuclear) (TOE1), mRNA. AK024011 - Homo sapiens cDNA FLJ13949 fis, clone Y79AA1001041. AK298162 - Homo sapiens cDNA FLJ57546 complete cds, highly similar to Homo sapiens target of EGR1, member 1 (nuclear) (TOE1), mRNA. AK093320 - Homo sapiens cDNA FLJ36001 fis, clone TESTI2015213, highly similar to Homo sapiens target of EGR1, member 1 (nuclear) (TOE1), mRNA. BC009364 - Homo sapiens target of EGR1, member 1 (nuclear), mRNA (cDNA clone MGC:14971 IMAGE:4302712), complete cds. JF432181 - Synthetic construct Homo sapiens clone IMAGE:100073336 target of EGR1, member 1 (nuclear) (TOE1) gene, encodes complete protein. CU679325 - Synthetic construct Homo sapiens gateway clone IMAGE:100019735 5' read TOE1 mRNA. CR457320 - Homo sapiens full open reading frame cDNA clone RZPDo834F0313D for gene TOE1, target of EGR1, member 1 (nuclear); complete cds, incl. stopcodon. DQ585191 - Homo sapiens piRNA piR-52303, complete sequence.