ID:JMY_HUMAN DESCRIPTION: RecName: Full=Junction-mediating and -regulatory protein; FUNCTION: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). SUBUNIT: Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5 (By similarity). INTERACTION: Q00987:MDM2; NbExp=2; IntAct=EBI-866435, EBI-389668; SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm, cytoskeleton. Note=Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil- like cells. INDUCTION: By E2F. PTM: Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response (By similarity). SIMILARITY: Belongs to the JMY family. SIMILARITY: Contains 1 WH2 domain. SEQUENCE CAUTION: Sequence=AAI30625.1; Type=Erroneous initiation; Sequence=BAC04495.1; Type=Erroneous initiation; Sequence=EAW95834.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02205 - WH2 motif PF15871 - Junction-mediating and -regulatory protein PF15920 - N-terminal of Junction-mediating and WASP homolog-associated
ModBase Predicted Comparative 3D Structure on Q8N9B5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006974 cellular response to DNA damage stimulus GO:0007050 cell cycle arrest GO:0034314 Arp2/3 complex-mediated actin nucleation GO:0043065 positive regulation of apoptotic process GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0070060 'de novo' actin filament nucleation GO:0070358 actin polymerization-dependent cell motility GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator
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