Human Gene RNF26 (uc001pwh.3)
  Description: Homo sapiens ring finger protein 26 (RNF26), mRNA.
RefSeq Summary (NM_032015): The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Transcript (Including UTRs)
   Position: hg19 chr11:119,205,210-119,208,024 Size: 2,815 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr11:119,205,833-119,207,134 Size: 1,302 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:119,205,210-119,208,024)mRNA (may differ from genome)Protein (433 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RNF26_HUMAN
DESCRIPTION: RecName: Full=RING finger protein 26;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Ubiquitous. Up-regulated in several cancer cell lines.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RNF26
CDC HuGE Published Literature: RNF26

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.09 RPKM in Esophagus - Muscularis
Total median expression: 613.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -212.18623-0.341 Picture PostScript Text
3' UTR -336.70890-0.378 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF13920 - Zinc finger, C3HC4 type (RING finger)

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q9BY78
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsemblFlyBase  
 Protein SequenceProtein SequenceProtein Sequence  
 AlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0007032 endosome organization
GO:0016567 protein ubiquitination
GO:0032479 regulation of type I interferon production
GO:0050687 negative regulation of defense response to virus
GO:0070979 protein K11-linked ubiquitination
GO:1905719 protein localization to perinuclear region of cytoplasm

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BX648447 - Homo sapiens mRNA; cDNA DKFZp686J03259 (from clone DKFZp686J03259).
BX647424 - Homo sapiens mRNA; cDNA DKFZp686F01152 (from clone DKFZp686F01152).
AK122642 - Homo sapiens cDNA FLJ16070 fis, clone HSYRA1000062, highly similar to RING finger protein 26.
BC000058 - Homo sapiens ring finger protein 26, mRNA (cDNA clone MGC:2642 IMAGE:3507662), complete cds.
AK075379 - Homo sapiens cDNA PSEC0069 fis, clone NT2RP2001341, highly similar to RING finger protein 26.
BC007534 - Homo sapiens ring finger protein 26, mRNA (cDNA clone MGC:15384 IMAGE:3028875), complete cds.
AB055622 - Homo sapiens mRNA for RING finger protein with leucine zipper RNF26, complete cds.
JD411432 - Sequence 392456 from Patent EP1572962.
CU675689 - Synthetic construct Homo sapiens gateway clone IMAGE:100017256 5' read RNF26 mRNA.
DQ893501 - Synthetic construct clone IMAGE:100006131; FLH194458.01X; RZPDo839B0780D ring finger protein 26 (RNF26) gene, encodes complete protein.
DQ896454 - Synthetic construct Homo sapiens clone IMAGE:100010914; FLH194454.01L; RZPDo839B0770D ring finger protein 26 (RNF26) gene, encodes complete protein.
KJ899527 - Synthetic construct Homo sapiens clone ccsbBroadEn_08921 RNF26 gene, encodes complete protein.
LF211594 - JP 2014500723-A/19097: Polycomb-Associated Non-Coding RNAs.
LF381743 - JP 2014500723-A/189246: Polycomb-Associated Non-Coding RNAs.
LF381744 - JP 2014500723-A/189247: Polycomb-Associated Non-Coding RNAs.
LF381745 - JP 2014500723-A/189248: Polycomb-Associated Non-Coding RNAs.
LF381746 - JP 2014500723-A/189249: Polycomb-Associated Non-Coding RNAs.
LF381747 - JP 2014500723-A/189250: Polycomb-Associated Non-Coding RNAs.
JD402355 - Sequence 383379 from Patent EP1572962.
JD399773 - Sequence 380797 from Patent EP1572962.
JD136822 - Sequence 117846 from Patent EP1572962.
JD563198 - Sequence 544222 from Patent EP1572962.
JD330034 - Sequence 311058 from Patent EP1572962.
JD152790 - Sequence 133814 from Patent EP1572962.
JD433189 - Sequence 414213 from Patent EP1572962.
JD300098 - Sequence 281122 from Patent EP1572962.
JD255204 - Sequence 236228 from Patent EP1572962.
JD422670 - Sequence 403694 from Patent EP1572962.
JD536799 - Sequence 517823 from Patent EP1572962.
JD257259 - Sequence 238283 from Patent EP1572962.
JD222057 - Sequence 203081 from Patent EP1572962.
JD195071 - Sequence 176095 from Patent EP1572962.
JD425218 - Sequence 406242 from Patent EP1572962.
JD268969 - Sequence 249993 from Patent EP1572962.
JD271147 - Sequence 252171 from Patent EP1572962.
JD282716 - Sequence 263740 from Patent EP1572962.
JD298588 - Sequence 279612 from Patent EP1572962.
JD097946 - Sequence 78970 from Patent EP1572962.
JD445627 - Sequence 426651 from Patent EP1572962.
JD078154 - Sequence 59178 from Patent EP1572962.
MA447171 - JP 2018138019-A/19097: Polycomb-Associated Non-Coding RNAs.
MA617320 - JP 2018138019-A/189246: Polycomb-Associated Non-Coding RNAs.
MA617321 - JP 2018138019-A/189247: Polycomb-Associated Non-Coding RNAs.
MA617322 - JP 2018138019-A/189248: Polycomb-Associated Non-Coding RNAs.
MA617323 - JP 2018138019-A/189249: Polycomb-Associated Non-Coding RNAs.
MA617324 - JP 2018138019-A/189250: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_032015, NP_114404, Q542Y8, Q9BY78, RNF26_HUMAN
UCSC ID: uc001pwh.3
RefSeq Accession: NM_032015
Protein: Q9BY78 (aka RNF26_HUMAN or RN26_HUMAN)
CCDS: CCDS8419.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032015.4
exon count: 1CDS single in 3' UTR: no RNA size: 2836
ORF size: 1302CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2591.00frame shift in genome: no % Coverage: 99.26
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.