Human Gene HMMR (uc003lzh.3)
  Description: Homo sapiens hyaluronan-mediated motility receptor (RHAMM) (HMMR), transcript variant 1, mRNA.
RefSeq Summary (NM_001142556): The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008].
Transcript (Including UTRs)
   Position: hg19 chr5:162,887,517-162,918,953 Size: 31,437 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr5:162,887,699-162,918,170 Size: 30,472 Coding Exon Count: 18 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:162,887,517-162,918,953)mRNA (may differ from genome)Protein (725 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMalacardsMGIOMIM
PubMedReactomeTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): HMMR
CDC HuGE Published Literature: HMMR
Positive Disease Associations: Insulin
Related Studies:
  1. Insulin
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: HMMR
Diseases sorted by gene-association score: breast cancer* (129), fibrosarcoma (4), leukemia, acute myeloid (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.94 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 51.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.10182-0.308 Picture PostScript Text
3' UTR -163.28783-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15905 - Hyaluronan mediated motility receptor N-terminal
PF15908 - Hyaluronan mediated motility receptor C-terminal

ModBase Predicted Comparative 3D Structure on O75330-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AY623426 - Homo sapiens hyaluronan-mediated motility receptor (HMMR) mRNA, complete sequence.
LF384717 - JP 2014500723-A/192220: Polycomb-Associated Non-Coding RNAs.
BC057235 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:6616448), partial cds.
AK313603 - Homo sapiens cDNA, FLJ94172.
BC030505 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:3919885), partial cds.
BC006984 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:3997460), partial cds.
AK302975 - Homo sapiens cDNA FLJ53375 complete cds, highly similar to Hyaluronan mediated motility receptor.
AK303616 - Homo sapiens cDNA FLJ53429 complete cds, highly similar to Hyaluronan mediated motility receptor.
BC070281 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:4063479), partial cds.
BC017793 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:4698833), partial cds.
U29343 - Homo sapiens hyaluronan receptor (RHAMM) mRNA, complete cds.
AF032862 - Homo sapiens intracellular hyaluronic acid binding protein (IHABP) mRNA, complete cds.
BC108904 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone MGC:119494 IMAGE:40007903), complete cds.
BC108905 - Homo sapiens cDNA clone IMAGE:40007904, containing frame-shift errors.
BC107869 - Homo sapiens cDNA clone IMAGE:4724268, containing frame-shift errors.
AK290577 - Homo sapiens cDNA FLJ75647 complete cds, highly similar to Homo sapiens hyaluronan-mediated motility receptor (RHAMM) (HMMR), transcript variant 2, mRNA.
KJ901492 - Synthetic construct Homo sapiens clone ccsbBroadEn_10886 HMMR gene, encodes complete protein.
KJ896989 - Synthetic construct Homo sapiens clone ccsbBroadEn_06383 HMMR gene, encodes complete protein.
BC033568 - Homo sapiens, Similar to hyaluronan-mediated motility receptor (RHAMM), clone IMAGE:4777447, mRNA.
LF325429 - JP 2014500723-A/132932: Polycomb-Associated Non-Coding RNAs.
LF325428 - JP 2014500723-A/132931: Polycomb-Associated Non-Coding RNAs.
LF325426 - JP 2014500723-A/132929: Polycomb-Associated Non-Coding RNAs.
JD566406 - Sequence 547430 from Patent EP1572962.
JD289217 - Sequence 270241 from Patent EP1572962.
JD528654 - Sequence 509678 from Patent EP1572962.
DM110835 - Novel Cancer Marker and Use Thereof.
JD083463 - Sequence 64487 from Patent EP1572962.
JD424540 - Sequence 405564 from Patent EP1572962.
JD376952 - Sequence 357976 from Patent EP1572962.
LF325425 - JP 2014500723-A/132928: Polycomb-Associated Non-Coding RNAs.
MA620294 - JP 2018138019-A/192220: Polycomb-Associated Non-Coding RNAs.
MA561006 - JP 2018138019-A/132932: Polycomb-Associated Non-Coding RNAs.
MA561005 - JP 2018138019-A/132931: Polycomb-Associated Non-Coding RNAs.
MA561003 - JP 2018138019-A/132929: Polycomb-Associated Non-Coding RNAs.
MA561002 - JP 2018138019-A/132928: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04512 - ECM-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein O75330 (Reactome details) participates in the following event(s):

R-HSA-8853405 TPX2 binds AURKA at centrosomes
R-HSA-2160915 Receptor-mediated uptake of HA
R-HSA-8853419 TPX2 promotes AURKA autophosphorylation
R-HSA-2160884 HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-69275 G2/M Transition
R-HSA-2142845 Hyaluronan metabolism
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1640170 Cell Cycle
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: IHABP, NM_001142556, NP_001136028, O75330-3, RHAMM
UCSC ID: uc003lzh.3
RefSeq Accession: NM_001142556
Protein: O75330-3, splice isoform of O75330 CCDS: CCDS4362.1, CCDS4363.1, CCDS47334.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001142556.1
exon count: 18CDS single in 3' UTR: no RNA size: 3144
ORF size: 2178CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4423.00frame shift in genome: no % Coverage: 99.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.