Description: Homo sapiens non-SMC condensin I complex, subunit G (NCAPG), transcript variant 1, mRNA. RefSeq Summary (NM_022346): This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. Transcript (Including UTRs) Position: hg19 chr4:17,812,436-17,846,487 Size: 34,052 Total Exon Count: 21 Strand: + Coding Region Position: hg19 chr4:17,812,701-17,845,048 Size: 32,348 Coding Exon Count: 21
ID:CND3_HUMAN DESCRIPTION: RecName: Full=Condensin complex subunit 3; AltName: Full=Chromosome-associated protein G; AltName: Full=Condensin subunit CAP-G; Short=hCAP-G; AltName: Full=Melanoma antigen NY-MEL-3; AltName: Full=Non-SMC condensin I complex subunit G; AltName: Full=XCAP-G homolog; FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. SUBUNIT: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. TISSUE SPECIFICITY: Highly expressed in testis. PTM: Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity). MISCELLANEOUS: Overexpressed in some cancer lines and some tumor cells. SIMILARITY: Belongs to the CND3 (condensin subunit 3) family. SIMILARITY: Contains 10 HEAT repeats. SEQUENCE CAUTION: Sequence=AAH00827.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB55165.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): NCAPG CDC HuGE Published Literature: NCAPG Positive Disease Associations: height Related Studies:
height Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15.
[PubMed 18391951]
height Okada ,et al. Hum Mol Genet 2010, A genome-wide association study in 19,633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci , Human molecular genetics 2010 .
[PubMed 20189936]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BPX3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
