Human Gene ZNF623 (uc003yzd.2)
Description: Homo sapiens zinc finger protein 623 (ZNF623), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr8:144,731,954-144,735,900 Size: 3,947 Total Exon Count: 1 Strand: +
Coding Region
Position: hg19 chr8:144,732,043-144,733,653 Size: 1,611 Coding Exon Count: 1
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ZN623_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 623;
FUNCTION: May be involved in transcriptional regulation.SUBCELLULAR LOCATION: Nucleus (Potential).SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.SIMILARITY: Contains 13 C2H2-type zinc fingers.SEQUENCE CAUTION: Sequence=BAA31603.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
Pfam Domains: PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger
SCOP Domains: 48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger
ModBase Predicted Comparative 3D Structure on O75123
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Component: GO:0005634 nucleus
Descriptions from all associated GenBank mRNAs
AK294695 - Homo sapiens cDNA FLJ53783 complete cds, highly similar to Zinc finger protein 623.BC112898 - Homo sapiens cDNA clone IMAGE:4399477, containing frame-shift errors.AB014528 - Homo sapiens KIAA0628 mRNA for KIAA0628 protein.JD234763 - Sequence 215787 from Patent EP1572962.JD373509 - Sequence 354533 from Patent EP1572962.BC067516 - Homo sapiens zinc finger protein 623, mRNA (cDNA clone MGC:79416 IMAGE:7002215), complete cds.BC067517 - Homo sapiens zinc finger protein 623, mRNA (cDNA clone MGC:79417 IMAGE:7002216), complete cds.BC067518 - Homo sapiens zinc finger protein 623, mRNA (cDNA clone MGC:79418 IMAGE:7002218), complete cds.JD255151 - Sequence 236175 from Patent EP1572962.BC075056 - Homo sapiens zinc finger protein 623, mRNA (cDNA clone MGC:103965 IMAGE:30915366), complete cds.BC075057 - Homo sapiens zinc finger protein 623, mRNA (cDNA clone MGC:104128 IMAGE:30915582), complete cds.JD447903 - Sequence 428927 from Patent EP1572962.AB463373 - Synthetic construct DNA, clone: pF1KA0628, Homo sapiens ZNF623 gene for zinc finger protein 623, without stop codon, in Flexi system.EU446754 - Synthetic construct Homo sapiens clone IMAGE:100069936; IMAGE:100011963; FLH257051.01L zinc finger protein 623 (ZNF623) gene, encodes complete protein.BC112899 - Homo sapiens zinc finger protein 623, mRNA (cDNA clone IMAGE:4441827), partial cds.JD314816 - Sequence 295840 from Patent EP1572962.JD314817 - Sequence 295841 from Patent EP1572962.JD027533 - Sequence 8557 from Patent EP1572962.JD032199 - Sequence 13223 from Patent EP1572962.JD314814 - Sequence 295838 from Patent EP1572962.JD314815 - Sequence 295839 from Patent EP1572962.JD183522 - Sequence 164546 from Patent EP1572962.JD232083 - Sequence 213107 from Patent EP1572962.JD250077 - Sequence 231101 from Patent EP1572962.JD355348 - Sequence 336372 from Patent EP1572962.JD325688 - Sequence 306712 from Patent EP1572962.JD254888 - Sequence 235912 from Patent EP1572962.JD149655 - Sequence 130679 from Patent EP1572962.JD143269 - Sequence 124293 from Patent EP1572962.JD227238 - Sequence 208262 from Patent EP1572962.JD526160 - Sequence 507184 from Patent EP1572962.JD072800 - Sequence 53824 from Patent EP1572962.JD197529 - Sequence 178553 from Patent EP1572962.JD554396 - Sequence 535420 from Patent EP1572962.JD414620 - Sequence 395644 from Patent EP1572962.JD203237 - Sequence 184261 from Patent EP1572962.JD421259 - Sequence 402283 from Patent EP1572962.JD299964 - Sequence 280988 from Patent EP1572962.JD251614 - Sequence 232638 from Patent EP1572962.JD250587 - Sequence 231611 from Patent EP1572962.JD095084 - Sequence 76108 from Patent EP1572962.JD222132 - Sequence 203156 from Patent EP1572962.JD194072 - Sequence 175096 from Patent EP1572962.JD450998 - Sequence 432022 from Patent EP1572962.JD328153 - Sequence 309177 from Patent EP1572962.JD298293 - Sequence 279317 from Patent EP1572962.JD427628 - Sequence 408652 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: KIAA0628, NM_014789, NP_055604, O75123, ZN623_HUMANUCSC ID: uc003yzd.2RefSeq Accession: NM_014789
Protein: O75123
(aka ZN623_HUMAN or Z623_HUMAN)
CCDS: CCDS34957.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_014789.3
exon count:
1 CDS single in 3' UTR:
no
RNA size:
3947
ORF size:
1611 CDS single in intron:
no
Alignment % ID:
99.95
txCdsPredict score:
3302.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.