Human Gene MIGA1 (uc010ork.3)
  Description: Homo sapiens family with sequence similarity 73, member A (MIGA1), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:78,245,309-78,345,225 Size: 99,917 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr1:78,245,341-78,340,749 Size: 95,409 Coding Exon Count: 16 

Page IndexSequence and LinksPrimersGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:78,245,309-78,345,225)mRNA (may differ from genome)Protein (633 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
LynxMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.28 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 151.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.6032-0.206 Picture PostScript Text
3' UTR -1223.794476-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019392 - DUF2217

Pfam Domains:
PF10265 - Mitoguardin

ModBase Predicted Comparative 3D Structure on B7ZLZ8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0008053 mitochondrial fusion

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BX537792 - Homo sapiens mRNA; cDNA DKFZp686M07166 (from clone DKFZp686M07166); complete cds.
BC130387 - Homo sapiens family with sequence similarity 73, member A, mRNA (cDNA clone MGC:163259 IMAGE:40146418), complete cds.
BC144167 - Homo sapiens family with sequence similarity 73, member A, mRNA (cDNA clone MGC:177704 IMAGE:9052687), complete cds.
AK296411 - Homo sapiens cDNA FLJ54361 complete cds.
AK092412 - Homo sapiens cDNA FLJ35093 fis, clone PLACE6006137.
AX747532 - Sequence 1057 from Patent EP1308459.
BX641170 - Homo sapiens mRNA; cDNA DKFZp686K12247 (from clone DKFZp686K12247).
U02055 - Human clone 13 Alu repeat sequence.
JD335281 - Sequence 316305 from Patent EP1572962.
JD387955 - Sequence 368979 from Patent EP1572962.
JD118045 - Sequence 99069 from Patent EP1572962.
JD138412 - Sequence 119436 from Patent EP1572962.
JD066631 - Sequence 47655 from Patent EP1572962.
JD176445 - Sequence 157469 from Patent EP1572962.
JD183910 - Sequence 164934 from Patent EP1572962.
JD280445 - Sequence 261469 from Patent EP1572962.
JD135801 - Sequence 116825 from Patent EP1572962.
JD238374 - Sequence 219398 from Patent EP1572962.
JD047622 - Sequence 28646 from Patent EP1572962.
JD243197 - Sequence 224221 from Patent EP1572962.
JD079526 - Sequence 60550 from Patent EP1572962.
JD457017 - Sequence 438041 from Patent EP1572962.
JD117520 - Sequence 98544 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZLZ8, B7ZLZ8_HUMAN, FAM73A, NM_001270384, NP_001257313, uc010ork.2
UCSC ID: uc010ork.3
RefSeq Accession: NM_001270384
Protein: B7ZLZ8 CCDS: CCDS681.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001270384.1
exon count: 16CDS single in 3' UTR: no RNA size: 6427
ORF size: 1902CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3808.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.