Human Gene LST1 (uc010jss.2) Description and Page Index
Description: Homo sapiens leukocyte specific transcript 1 (LST1), transcript variant 2, mRNA. RefSeq Summary (NM_205837): The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: hg19 chr6:31,554,476-31,556,686 Size: 2,211 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr6:31,555,077-31,556,362 Size: 1,286 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5STA8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BX647293 - Homo sapiens mRNA; cDNA DKFZp781G1336 (from clone DKFZp781G1336). AF000425 - Homo sapiens LST1 mRNA, cLST1/A splice variant, complete cds. AF000424 - Homo sapiens LST1 mRNA, cLST1/C splice variant, complete cds. JD537486 - Sequence 518510 from Patent EP1572962. JD282930 - Sequence 263954 from Patent EP1572962. JD343127 - Sequence 324151 from Patent EP1572962. AF000426 - Homo sapiens LST1 mRNA, cLST1/E splice variant, complete cds. BC103855 - Homo sapiens leukocyte specific transcript 1, mRNA (cDNA clone MGC:119006 IMAGE:40003000), complete cds. BC103856 - Homo sapiens leukocyte specific transcript 1, mRNA (cDNA clone MGC:119007 IMAGE:40003004), complete cds. Y18486 - Homo sapiens mRNA for LST-1/J protein. Y18487 - Homo sapiens mRNA for LST-1/K protein. Y18488 - Homo sapiens mRNA for LST-1/L protein, partial. Y18489 - Homo sapiens mRNA for LST-1/M protein. Y18490 - Homo sapiens mRNA for LST-1/N protein. AY852265 - Homo sapiens LST1/O mRNA, complete cds, alternatively spliced. AY852266 - Homo sapiens LST1/P mRNA, complete cds, alternatively spliced. KJ892452 - Synthetic construct Homo sapiens clone ccsbBroadEn_01846 LST1 gene, encodes complete protein. DQ099382 - Homo sapiens leukocyte specific transcript 1 mRNA, complete cds, alternatively spliced.