Human Gene TLR8 (uc004cve.3) Description and Page Index
Description: Homo sapiens toll-like receptor 8 (TLR8), mRNA. RefSeq Summary (NM_138636): The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chrX:12,924,739-12,941,288 Size: 16,550 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chrX:12,924,826-12,940,285 Size: 15,460 Coding Exon Count: 2
ID:TLR8_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 8; AltName: CD_antigen=CD288; Flags: Precursor; FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. SUBUNIT: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Interacts with BTK. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 23 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SIMILARITY: Contains 1 TIR domain.
Genetic Association Studies of Complex Diseases and Disorders
HIV Infections D-Y Oh , et al. The Journal of infectious diseases 2008 198(5):701-9, A functional toll-like receptor 8 variant is associated with HIV disease restriction., The Journal of infectious diseases 2008 198(5):701-9.
This first report of a functional TLR8 variant associated with a different clinical course of an RNA viral disease may have implications for the individual risk assessment of patients infected with HIV and other RNA viruses as well as for future HIV vacci
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 52200 - Toll/Interleukin receptor TIR domain
ModBase Predicted Comparative 3D Structure on Q9NR97
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-1678923 TLR folding by chaperones GP96 and CNPY3 R-HSA-1678944 Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex R-HSA-167983 Ligand binds to TLR7 or TLR8 R-HSA-1678921 Full-length TLR3/7/8/9 binds to UNC93B1 R-HSA-975175 MyD88 interacts with the activated TLR receptor 7, 8 or 9 R-HSA-975156 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex R-HSA-975098 MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 R-HSA-975115 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. R-HSA-975100 Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex R-HSA-975170 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 R-HSA-975125 Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975134 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 R-HSA-975180 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 R-HSA-975111 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975188 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation R-HSA-975106 Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling