Human Gene FUT7 (uc004ckq.2) Description and Page Index
  Description: Homo sapiens fucosyltransferase 7 (alpha (1,3) fucosyltransferase) (FUT7), mRNA.
RefSeq Summary (NM_004479): The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086312.1, X78031.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr9:139,924,626-139,927,292 Size: 2,667 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr9:139,925,162-139,926,443 Size: 1,282 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:139,924,626-139,927,292)mRNA (may differ from genome)Protein (342 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: FUT7_HUMAN
DESCRIPTION: RecName: Full=Alpha-(1,3)-fucosyltransferase; EC=2.4.1.-; AltName: Full=Fucosyltransferase 7; AltName: Full=Fucosyltransferase VII; Short=Fuc-TVII; Short=FucT-VII; AltName: Full=Galactoside 3-L-fucosyltransferase; AltName: Full=Selectin ligand synthase;
FUNCTION: May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.
CATALYTIC ACTIVITY: GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4- beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu- N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D- glucosaminyl-R.
PATHWAY: Protein modification; protein glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
TISSUE SPECIFICITY: Leukocytic/myeloid lineage cells.
SIMILARITY: Belongs to the glycosyltransferase 10 family.
WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT7";
WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 7; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_604";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FUT7
CDC HuGE Published Literature: FUT7

-  MalaCards Disease Associations
  MalaCards Gene Search: FUT7
Diseases sorted by gene-association score: ehrlichiosis (23), human granulocytic anaplasmosis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.41 RPKM in Whole Blood
Total median expression: 47.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -421.59849-0.497 Picture PostScript Text
3' UTR -246.46536-0.460 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001503 - Glyco_trans_10

Pfam Domains:
PF00852 - Glycosyltransferase family 10 (fucosyltransferase) C-term
PF17039 - Fucosyltransferase, N-terminal

ModBase Predicted Comparative 3D Structure on Q11130
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
 Protein SequenceProtein Sequence Protein Sequence 
 AlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008417 fucosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0046920 alpha-(1->3)-fucosyltransferase activity

Biological Process:
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002522 leukocyte migration involved in immune response
GO:0006486 protein glycosylation
GO:0006672 ceramide metabolic process
GO:0036065 fucosylation
GO:0042355 L-fucose catabolic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane


-  Descriptions from all associated GenBank mRNAs
  LF205585 - JP 2014500723-A/13088: Polycomb-Associated Non-Coding RNAs.
X78031 - H.sapiens mRNA for alpha-1,3-fucosyl-transferase.
BC086312 - Homo sapiens fucosyltransferase 7 (alpha (1,3) fucosyltransferase), mRNA (cDNA clone MGC:99836 IMAGE:6651145), complete cds.
JD425944 - Sequence 406968 from Patent EP1572962.
JD215769 - Sequence 196793 from Patent EP1572962.
JD318797 - Sequence 299821 from Patent EP1572962.
JD225613 - Sequence 206637 from Patent EP1572962.
JD156855 - Sequence 137879 from Patent EP1572962.
JD269491 - Sequence 250515 from Patent EP1572962.
JD127678 - Sequence 108702 from Patent EP1572962.
JD136915 - Sequence 117939 from Patent EP1572962.
JD383830 - Sequence 364854 from Patent EP1572962.
JD223262 - Sequence 204286 from Patent EP1572962.
JD055665 - Sequence 36689 from Patent EP1572962.
JD341891 - Sequence 322915 from Patent EP1572962.
JD535169 - Sequence 516193 from Patent EP1572962.
JD177333 - Sequence 158357 from Patent EP1572962.
JD374278 - Sequence 355302 from Patent EP1572962.
U08112 - Human alpha(1,3)fucosyltransferase mRNA, complete cds.
U11282 - Human alpha(1,3)fucosyltransferase mRNA, complete cds.
JD445244 - Sequence 426268 from Patent EP1572962.
JD503789 - Sequence 484813 from Patent EP1572962.
JD086268 - Sequence 67292 from Patent EP1572962.
JD223774 - Sequence 204798 from Patent EP1572962.
JD545146 - Sequence 526170 from Patent EP1572962.
JD231591 - Sequence 212615 from Patent EP1572962.
BC074746 - Homo sapiens fucosyltransferase 7 (alpha (1,3) fucosyltransferase), mRNA (cDNA clone MGC:103824 IMAGE:30915206), complete cds.
AK313124 - Homo sapiens cDNA, FLJ93609, Homo sapiens fucosyltransferase 7 (alpha (1,3) fucosyltransferase)(FUT7), mRNA.
KJ891205 - Synthetic construct Homo sapiens clone ccsbBroadEn_00599 FUT7 gene, encodes complete protein.
KR712091 - Synthetic construct Homo sapiens clone CCSBHm_00035701 FUT7 (FUT7) mRNA, encodes complete protein.
LF212874 - JP 2014500723-A/20377: Polycomb-Associated Non-Coding RNAs.
LF211796 - JP 2014500723-A/19299: Polycomb-Associated Non-Coding RNAs.
BC032357 - Homo sapiens fucosyltransferase 7 (alpha (1,3) fucosyltransferase), mRNA (cDNA clone IMAGE:5219509), with apparent retained intron.
JD337338 - Sequence 318362 from Patent EP1572962.
LF346329 - JP 2014500723-A/153832: Polycomb-Associated Non-Coding RNAs.
MA581906 - JP 2018138019-A/153832: Polycomb-Associated Non-Coding RNAs.
MA441162 - JP 2018138019-A/13088: Polycomb-Associated Non-Coding RNAs.
MA448451 - JP 2018138019-A/20377: Polycomb-Associated Non-Coding RNAs.
MA447373 - JP 2018138019-A/19299: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00601 - Glycosphingolipid biosynthesis - lacto and neolacto series

BioCarta from NCI Cancer Genome Anatomy Project
h_aMANpathway - Steps in the Glycosylation of Mammalian N-linked Oligosaccarides

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7U7, FUT7_HUMAN, NM_004479, NP_004470, Q11130, Q6DK54
UCSC ID: uc004ckq.2
RefSeq Accession: NM_004479
Protein: Q11130 (aka FUT7_HUMAN)
CCDS: CCDS7022.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004479.3
exon count: 2CDS single in 3' UTR: no RNA size: 2428
ORF size: 1029CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 568.00frame shift in genome: no % Coverage: 99.42
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.