Human Gene P2RY13 (uc003eyv.2) Description and Page Index
  Description: Homo sapiens purinergic receptor P2Y, G-protein coupled, 13 (P2RY13), mRNA.
RefSeq Summary (NM_176894): The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041116.1, SRR3476690.845925.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000325602.6/ ENSP00000320376.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr3:151,044,096-151,047,337 Size: 3,242 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr3:151,045,779-151,047,316 Size: 1,538 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:151,044,096-151,047,337)mRNA (may differ from genome)Protein (354 aa)
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-  Comments and Description Text from UniProtKB
  ID: P2Y13_HUMAN
DESCRIPTION: RecName: Full=P2Y purinoceptor 13; Short=P2Y13; AltName: Full=G-protein coupled receptor 86; AltName: Full=G-protein coupled receptor 94;
FUNCTION: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.
MISCELLANEOUS: Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAH29363.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH41116.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): P2RY13
CDC HuGE Published Literature: P2RY13

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.56 RPKM in Whole Blood
Total median expression: 101.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.3021-0.062 Picture PostScript Text
3' UTR -386.301683-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor
IPR008109 - P2Y13_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2B6U
- Model


ModBase Predicted Comparative 3D Structure on Q9BPV8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0045028 G-protein coupled purinergic nucleotide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0008150 biological_process
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0071407 cellular response to organic cyclic compound

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF295368 - Homo sapiens G-protein coupled receptor GPR86 (GPR86) mRNA, complete cds.
BC041116 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 13, mRNA (cDNA clone MGC:47584 IMAGE:5173463), complete cds.
JD264939 - Sequence 245963 from Patent EP1572962.
JD254786 - Sequence 235810 from Patent EP1572962.
JD188956 - Sequence 169980 from Patent EP1572962.
JD432060 - Sequence 413084 from Patent EP1572962.
JD066972 - Sequence 47996 from Patent EP1572962.
JD123318 - Sequence 104342 from Patent EP1572962.
JD390879 - Sequence 371903 from Patent EP1572962.
JD412116 - Sequence 393140 from Patent EP1572962.
JD052855 - Sequence 33879 from Patent EP1572962.
JD137249 - Sequence 118273 from Patent EP1572962.
AF178982 - Homo sapiens putative G protein-coupled receptor GPCR1 precursor, mRNA, complete cds.
JD037017 - Sequence 18041 from Patent EP1572962.
JD504253 - Sequence 485277 from Patent EP1572962.
AF345565 - Homo sapiens putative G-protein-coupled receptor FKSG77 (FKSG77) mRNA, complete cds.
JD185038 - Sequence 166062 from Patent EP1572962.
BC066887 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 13, mRNA (cDNA clone IMAGE:6971822), partial cds.
JD314362 - Sequence 295386 from Patent EP1572962.
JD082589 - Sequence 63613 from Patent EP1572962.
AF406692 - Homo sapiens G protein-coupled receptor GPR86 mRNA, complete cds.
JF810883 - Homo sapiens purinergic receptor P2Y G-protein coupled 13 (P2RY13) mRNA, complete cds.
AK313208 - Homo sapiens cDNA, FLJ93709, Homo sapiens G protein-coupled receptor 86 (GPR86), mRNA.
KJ902629 - Synthetic construct Homo sapiens clone ccsbBroadEn_12023 P2RY13 gene, encodes complete protein.
AB464110 - Synthetic construct DNA, clone: pF1KB7140, Homo sapiens P2RY13 gene for purinergic receptor P2Y, G-protein coupled, 13, without stop codon, in Flexi system.
CU691956 - Synthetic construct Homo sapiens gateway clone IMAGE:100021133 5' read P2RY13 mRNA.
BC029363 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 13, mRNA (cDNA clone IMAGE:4732407), partial cds.
JD236705 - Sequence 217729 from Patent EP1572962.
JD271264 - Sequence 252288 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein Q9BPV8 (Reactome details) participates in the following event(s):

R-HSA-417843 P2Y13 receptor can bind ADP
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-417957 P2Y receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-418038 Nucleotide-like (purinergic) receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R827, FKSG77, GPR86, GPR94, NM_176894, NP_795713, P2Y13_HUMAN, Q05C50, Q6DKN4, Q8IUT5, Q8TDU7, Q9BPV8, Q9BY61
UCSC ID: uc003eyv.2
RefSeq Accession: NM_176894
Protein: Q9BPV8 (aka P2Y13_HUMAN)
CCDS: CCDS3158.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_176894.2
exon count: 2CDS single in 3' UTR: no RNA size: 2769
ORF size: 1065CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1744.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.