Human Gene LILRA5 (uc002qfe.3) Description and Page Index
Description: Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 (LILRA5), transcript variant 1, mRNA. RefSeq Summary (NM_021250): The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:54,818,353-54,824,409 Size: 6,057 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr19:54,818,698-54,824,289 Size: 5,592 Coding Exon Count: 7
ID:LIRA5_HUMAN DESCRIPTION: RecName: Full=Leukocyte immunoglobulin-like receptor subfamily A member 5; AltName: Full=CD85 antigen-like family member F; AltName: Full=Immunoglobulin-like transcript 11; Short=ILT-11; AltName: Full=Leukocyte immunoglobulin-like receptor 9; Short=LIR-9; AltName: CD_antigen=CD85f; Flags: Precursor; FUNCTION: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. SUBCELLULAR LOCATION: Isoform 2: Membrane; Single-pass type I membrane protein. Secreted. SUBCELLULAR LOCATION: Isoform 3: Secreted. SUBCELLULAR LOCATION: Isoform 4: Secreted. TISSUE SPECIFICITY: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level). SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LILRA5 CDC HuGE Published Literature: LILRA5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A6NI73
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.