Human Gene SIGLEC14 (uc002pxf.4) Description and Page Index
  Description: Homo sapiens sialic acid binding Ig-like lectin 14 (SIGLEC14), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:52,145,806-52,150,132 Size: 4,327 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr19:52,146,608-52,150,012 Size: 3,405 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:52,145,806-52,150,132)mRNA (may differ from genome)Protein (396 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Sialic acid-binding Ig-like lectin 14; Short=Siglec-14; Flags: Precursor;
FUNCTION: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.
SUBUNIT: Interacts with TYROBP.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis.
SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.87 RPKM in Whole Blood
Total median expression: 100.86 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.52120-0.463 Picture PostScript Text
3' UTR -201.29802-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003006 - Ig/MHC_CS
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set
IPR013151 - Immunoglobulin

Pfam Domains:
PF00047 - Immunoglobulin domain
PF07679 - Immunoglobulin I-set domain
PF07686 - Immunoglobulin V-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q08ET2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030246 carbohydrate binding

Biological Process:
GO:0007155 cell adhesion
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

-  Descriptions from all associated GenBank mRNAs
  AY854038 - Homo sapiens SIGLEC14 (SIGLEC14) mRNA, complete cds.
JD414815 - Sequence 395839 from Patent EP1572962.
JD397050 - Sequence 378074 from Patent EP1572962.
JD476727 - Sequence 457751 from Patent EP1572962.
JD560692 - Sequence 541716 from Patent EP1572962.
JD379672 - Sequence 360696 from Patent EP1572962.
JD256542 - Sequence 237566 from Patent EP1572962.
JD476728 - Sequence 457752 from Patent EP1572962.
JD560693 - Sequence 541717 from Patent EP1572962.
JD560691 - Sequence 541715 from Patent EP1572962.
AY358369 - Homo sapiens clone DNA41374 SIGLEC5 (UNQ294) mRNA, partial cds.
AK298284 - Homo sapiens cDNA FLJ56856 complete cds, highly similar to Sialic acid-binding Ig-like lectin 5 precursor.
JD398274 - Sequence 379298 from Patent EP1572962.
JD418168 - Sequence 399192 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q08ET2 (Reactome details) participates in the following event(s):

R-HSA-2172123 Interaction of SIGLEC14/15/16 and DAP12
R-HSA-6798747 Exocytosis of tertiary granule membrane proteins
R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins
R-HSA-2172127 DAP12 interactions
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001098612, NP_001092082, Q08ET2, Q6UXG0, SIG14_HUMAN, UNQ294/PRO333
UCSC ID: uc002pxf.4
RefSeq Accession: NM_001098612
Protein: Q08ET2 (aka SIG14_HUMAN)
CCDS: CCDS42604.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001098612.1
exon count: 7CDS single in 3' UTR: no RNA size: 2113
ORF size: 1191CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2552.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.