Human Gene CEACAM4 (uc002orh.1) Description and Page Index
  Description: Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:42,125,344-42,133,442 Size: 8,099 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr19:42,125,703-42,133,331 Size: 7,629 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:42,125,344-42,133,442)mRNA (may differ from genome)Protein (244 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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HGNCHPRDLynxMGIneXtProtPubMed
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CEAM4_HUMAN
DESCRIPTION: RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 4; AltName: Full=Carcinoembryonic antigen CGM7; AltName: Full=Non-specific cross-reacting antigen W236; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Granulocytes.
PTM: N-glycosylated.
SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.53 RPKM in Whole Blood
Total median expression: 88.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.40111-0.292 Picture PostScript Text
3' UTR -160.60359-0.447 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on O75871
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006909 phagocytosis

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  E03347 - cDNA sequence coding for human carcinoembryonic antigen (W236).
D90276 - Homo sapiens CGM7 gene for nonspecific cross-reacting antigen, complete cds.
JD495188 - Sequence 476212 from Patent EP1572962.
JD318178 - Sequence 299202 from Patent EP1572962.
JD190051 - Sequence 171075 from Patent EP1572962.
AB924370 - Homo sapiens CEACAM4 mRNA for carcinoembryonic antigen-related cell adhesion molecule 4-sv2, complete cds.
JD437338 - Sequence 418362 from Patent EP1572962.
BC172306 - Synthetic construct Homo sapiens clone IMAGE:100069000, MGC:199011 carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) mRNA, encodes complete protein.
AK298701 - Homo sapiens cDNA FLJ60787 complete cds, highly similar to Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4), mRNA.
AB924369 - Homo sapiens CEACAM4 mRNA for carcinoembryonic antigen-related cell adhesion molecule 4-sv1, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CEAM4_HUMAN, CGM7, NM_001817, NP_001808, O75871, Q03715, Q7LDZ7
UCSC ID: uc002orh.1
RefSeq Accession: NM_001817
Protein: O75871 (aka CEAM4_HUMAN)
CCDS: CCDS33033.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001817.2
exon count: 7CDS single in 3' UTR: no RNA size: 1205
ORF size: 735CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1670.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.