Human Gene PRAM1 (uc002mkd.3) Description and Page Index
  Description: Homo sapiens PML-RARA regulated adaptor molecule 1 (PRAM1), mRNA.
RefSeq Summary (NM_032152): The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028012.1, AK308227.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000423345.5/ ENSP00000408342.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr19:8,554,940-8,567,538 Size: 12,599 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr19:8,555,073-8,567,475 Size: 12,403 Coding Exon Count: 10 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:8,554,940-8,567,538)mRNA (may differ from genome)Protein (670 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PRAM1
CDC HuGE Published Literature: PRAM1
Positive Disease Associations: height
Related Studies:
  1. height
    Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15. [PubMed 18391951]

-  MalaCards Disease Associations
  MalaCards Gene Search: PRAM1
Diseases sorted by gene-association score: leukemia, acute promyelocytic, somatic (1), leukemia, acute myeloid (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.78 RPKM in Whole Blood
Total median expression: 105.13 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.3063-0.275 Picture PostScript Text
3' UTR -58.81133-0.442 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14603 - Helically-extended SH3 domain

SCOP Domains:
50044 - SH3-domain

ModBase Predicted Comparative 3D Structure on Q96QH2-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  LF210783 - JP 2014500723-A/18286: Polycomb-Associated Non-Coding RNAs.
BC028012 - Homo sapiens PML-RARA regulated adaptor molecule 1, mRNA (cDNA clone MGC:39864 IMAGE:5215850), complete cds.
AJ272324 - Homo sapiens mRNA for PRAM-1 protein.
AK308227 - Homo sapiens cDNA, FLJ98175.
JD443317 - Sequence 424341 from Patent EP1572962.
JD236784 - Sequence 217808 from Patent EP1572962.
DQ891057 - Synthetic construct clone IMAGE:100003687; FLH168902.01X; RZPDo839E0594D PML-RARA regulated adaptor molecule 1 (PRAM1) gene, encodes complete protein.
JD366873 - Sequence 347897 from Patent EP1572962.
KJ899756 - Synthetic construct Homo sapiens clone ccsbBroadEn_09150 PRAM1 gene, encodes complete protein.
EU176810 - Synthetic construct Homo sapiens clone IMAGE:100011558; FLH196263.01L; RZPDo839E07256D PML-RARA regulated adaptor molecule 1 (PRAM1) gene, encodes complete protein.
AB590302 - Synthetic construct DNA, clone: pFN21AE1490, Homo sapiens PRAM1 gene for PML-RARA regulated adaptor molecule 1, without stop codon, in Flexi system.
JD170303 - Sequence 151327 from Patent EP1572962.
LF341174 - JP 2014500723-A/148677: Polycomb-Associated Non-Coding RNAs.
JD339497 - Sequence 320521 from Patent EP1572962.
LF341172 - JP 2014500723-A/148675: Polycomb-Associated Non-Coding RNAs.
LF341170 - JP 2014500723-A/148673: Polycomb-Associated Non-Coding RNAs.
JD111486 - Sequence 92510 from Patent EP1572962.
MA446360 - JP 2018138019-A/18286: Polycomb-Associated Non-Coding RNAs.
MA576751 - JP 2018138019-A/148677: Polycomb-Associated Non-Coding RNAs.
MA576749 - JP 2018138019-A/148675: Polycomb-Associated Non-Coding RNAs.
MA576747 - JP 2018138019-A/148673: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_pmlPathway - Regulation of transcriptional activity by PML

-  Other Names for This Gene
  Alternate Gene Symbols: NM_032152, NP_115528, Q96QH2-2
UCSC ID: uc002mkd.3
RefSeq Accession: NM_032152
Protein: Q96QH2-2, splice isoform of Q96QH2 CCDS: CCDS45954.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_032152.4
exon count: 10CDS single in 3' UTR: no RNA size: 2235
ORF size: 2013CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3483.00frame shift in genome: no % Coverage: 98.84
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.