Human Gene CD300LF (uc002jlg.3) Description and Page Index
Description: Homo sapiens CD300 molecule-like family member f (CD300LF), mRNA. RefSeq Summary (NM_139018): This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Transcript (Including UTRs) Position: hg19 chr17:72,690,452-72,709,108 Size: 18,657 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr17:72,691,235-72,709,005 Size: 17,771 Coding Exon Count: 7
ID:CLM1_HUMAN DESCRIPTION: RecName: Full=CMRF35-like molecule 1; Short=CLM-1; AltName: Full=CD300 antigen-like family member F; AltName: Full=Immune receptor expressed on myeloid cells 1; Short=IREM-1; AltName: Full=Immunoglobulin superfamily member 13; Short=IgSF13; AltName: Full=NK inhibitory receptor; AltName: CD_antigen=CD300f; Flags: Precursor; FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. SUBUNIT: Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells. PTM: Phosphorylated on tyrosine. SIMILARITY: Belongs to the CD300 family. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CD300LF CDC HuGE Published Literature: CD300LF Positive Disease Associations: fibrinogen Related Studies:
fibrinogen Danik ,et al. 2009, Novel Loci, Including Those Related to Crohn Disease, Psoriasis, and Inflammation Identified in a Genome-Wide Association Study of Fibrinogen in 17,686 Women: The Women's Genome Health Study, Circulation. Cardiovascular genetics 2009 2- 2 : 134-41.
Fibrinogen Jacqueline S Danik et al. Circulation. Cardiovascular genetics 2009, Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study., Circulation. Cardiovascular genetics.
A genome-wide survey of the human genome identifies novel loci related to common chronic inflammatory diseases as genetic determinants of fibrinogen levels, in addition to loci that relate to the inflammatory cascade, the urea cycle, and the fibrinogen gene cluster.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDQ1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.