Human Gene IGSF6 (uc002djg.2) Description and Page Index
  Description: Homo sapiens immunoglobulin superfamily, member 6 (IGSF6), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:21,652,605-21,663,987 Size: 11,383 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr16:21,652,855-21,663,919 Size: 11,065 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:21,652,605-21,663,987)mRNA (may differ from genome)Protein (241 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Immunoglobulin superfamily member 6; Short=IgSF6; AltName: Full=Protein DORA; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in peripheral blood lymphocytes, spleen and lymph node, with low levels in thymus, bone marrow and fetal liver. No expression in non-immune tissues.
INDUCTION: By TNF and CSF2/GM-CSF in dendritic cells and down regulation by phorbol myristate acetate (PMA) and ionomycin in monocytes.
MISCELLANEOUS: This gene is localized to a locus associated with inflammatory bowel disease. It is coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA.
SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): IGSF6
CDC HuGE Published Literature: IGSF6

-  MalaCards Disease Associations
  MalaCards Gene Search: IGSF6
Diseases sorted by gene-association score: dysbaric osteonecrosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 71.78 RPKM in Whole Blood
Total median expression: 149.69 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.6068-0.141 Picture PostScript Text
3' UTR -37.32250-0.149 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on O95976
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity

Biological Process:
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK223286 - Homo sapiens mRNA for immunoglobulin superfamily, member 6 variant, clone: SYN03106.
BC017844 - Homo sapiens immunoglobulin superfamily, member 6, mRNA (cDNA clone MGC:22530 IMAGE:4616809), complete cds.
AJ223183 - Homo sapiens mRNA for DORA protein.
JD433889 - Sequence 414913 from Patent EP1572962.
AK290910 - Homo sapiens cDNA FLJ78097 complete cds, highly similar to Homo sapiens immunoglobulin superfamily, member 6 (IGSF6), mRNA.
JD324830 - Sequence 305854 from Patent EP1572962.
JD304865 - Sequence 285889 from Patent EP1572962.
JD530565 - Sequence 511589 from Patent EP1572962.
DQ892013 - Synthetic construct clone IMAGE:100004643; FLH182303.01X; RZPDo839E10138D immunoglobulin superfamily, member 6 (IGSF6) gene, encodes complete protein.
EU176227 - Synthetic construct Homo sapiens clone IMAGE:100006619; FLH264079.01X; RZPDo839E12257D immunoglobulin superfamily, member 6 (IGSF6) gene, encodes complete protein.
EU176324 - Synthetic construct Homo sapiens clone IMAGE:100006564; FLH263576.01X; RZPDo839G06251D immunoglobulin superfamily, member 6 (IGSF6) gene, encodes complete protein.
AK313860 - Homo sapiens cDNA, FLJ94492, highly similar to Homo sapiens immunoglobulin superfamily, member 6 (IGSF6), mRNA.
KJ898186 - Synthetic construct Homo sapiens clone ccsbBroadEn_07580 IGSF6 gene, encodes complete protein.
DQ895202 - Synthetic construct Homo sapiens clone IMAGE:100009662; FLH182299.01L; RZPDo839E10137D immunoglobulin superfamily, member 6 (IGSF6) gene, encodes complete protein.
AK293703 - Homo sapiens cDNA FLJ57907 complete cds, highly similar to Homo sapiens immunoglobulin superfamily, member 6 (IGSF6), mRNA.
KY994046 - Homo sapiens QXBT4 miRNA, complete sequence.
KY994068 - Homo sapiens precursor microRNA QXBT4, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: DORA, IGSF6_HUMAN, NM_005849, NP_005840, O95976, Q8WWD8
UCSC ID: uc002djg.2
RefSeq Accession: NM_005849
Protein: O95976 (aka IGSF6_HUMAN)
CCDS: CCDS10599.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_005849.3
exon count: 6CDS single in 3' UTR: no RNA size: 1062
ORF size: 726CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1652.00frame shift in genome: no % Coverage: 98.31
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.