Description: Homo sapiens granzyme H (cathepsin G-like 2, protein h-CCPX) (GZMH), transcript variant 1, mRNA. RefSeq Summary (NM_033423): This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]. Transcript (Including UTRs) Position: hg19 chr14:25,075,686-25,078,926 Size: 3,241 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr14:25,075,809-25,078,819 Size: 3,011 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20718
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP895950 - Sequence 814 from Patent EP3253886. LF210099 - JP 2014500723-A/17602: Polycomb-Associated Non-Coding RNAs. AY232658 - Homo sapiens granzyme H splice variant 3 mRNA, complete cds; alternatively spliced. BC027974 - Homo sapiens granzyme H (cathepsin G-like 2, protein h-CCPX), mRNA (cDNA clone MGC:34849 IMAGE:5229314), complete cds. AY232657 - Homo sapiens granzyme H splice variant 2 mRNA, complete cds; alternatively spliced. M36118 - Human cytotoxin serine protease-C mRNA, complete cds. JD220566 - Sequence 201590 from Patent EP1572962. JD077686 - Sequence 58710 from Patent EP1572962. CU693356 - Synthetic construct Homo sapiens gateway clone IMAGE:100016878 5' read GZMH mRNA. DQ892068 - Synthetic construct clone IMAGE:100004698; FLH182852.01X; RZPDo839C12140D granzyme H (cathepsin G-like 2, protein h-CCPX) (GZMH) gene, encodes complete protein. KJ891318 - Synthetic construct Homo sapiens clone ccsbBroadEn_00712 GZMH gene, encodes complete protein. DQ895261 - Synthetic construct Homo sapiens clone IMAGE:100009721; FLH182848.01L; RZPDo839C12139D granzyme H (cathepsin G-like 2, protein h-CCPX) (GZMH) gene, encodes complete protein. AB590301 - Synthetic construct DNA, clone: pFN21AE1560, Homo sapiens GZMH gene for granzyme H, without stop codon, in Flexi system. LF334602 - JP 2014500723-A/142105: Polycomb-Associated Non-Coding RNAs. LF334603 - JP 2014500723-A/142106: Polycomb-Associated Non-Coding RNAs. JD465365 - Sequence 446389 from Patent EP1572962. JD246089 - Sequence 227113 from Patent EP1572962. JD385978 - Sequence 367002 from Patent EP1572962. MA445676 - JP 2018138019-A/17602: Polycomb-Associated Non-Coding RNAs. MA570179 - JP 2018138019-A/142105: Polycomb-Associated Non-Coding RNAs. MA570180 - JP 2018138019-A/142106: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P20718 (Reactome details) participates in the following event(s):
R-HSA-381500 Cathepsin G proteolyzes IGF:IGFBP3:ALS R-HSA-2022411 Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins R-HSA-392499 Metabolism of proteins R-HSA-2980736 Peptide hormone metabolism