Human Gene CD247 (uc001gei.4) Description and Page Index
  Description: Homo sapiens CD247 molecule (CD247), transcript variant 1, mRNA.
RefSeq Summary (NM_198053): The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:167,399,877-167,487,847 Size: 87,971 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr1:167,400,918-167,487,702 Size: 86,785 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:167,399,877-167,487,847)mRNA (may differ from genome)Protein (164 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CD3Z_HUMAN
DESCRIPTION: RecName: Full=T-cell surface glycoprotein CD3 zeta chain; AltName: Full=T-cell receptor T3 zeta chain; AltName: CD_antigen=CD247; Flags: Precursor;
FUNCTION: Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1; this interaction up- regulates the expression of the Fas ligand (FASLG) at the cell surface. Interacts with HIV-2 Nef protein; this interaction induces down-regulation of cell surface TCR/CD3 complexes. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC.
INTERACTION: Self; NbExp=5; IntAct=EBI-1165705, EBI-1165705; Q9Y2R2:PTPN22; NbExp=4; IntAct=EBI-1165705, EBI-1211241;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: The ITAM domains mediate interaction with SHB.
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering (By similarity).
DISEASE: Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
SIMILARITY: Belongs to the CD3Z/FCER1G family.
SIMILARITY: Contains 3 ITAM domains.
WEB RESOURCE: Name=CD247base; Note=CD247 mutation db; URL="http://bioinf.uta.fi/CD247base/";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cd3z/";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CD247
CDC HuGE Published Literature: CD247
Positive Disease Associations: Arthritis, Rheumatoid , Autoimmune Diseases , Celiac disease , Scleroderma, Systemic , Sclerosis
Related Studies:
  1. Arthritis, Rheumatoid
    Eli A Stahl et al. Nature genetics 2010, Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci., Nature genetics. [PubMed 20453842]
  2. Autoimmune Diseases
    Alexandra Zhernakova et al. PLoS genetics 2011, Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci., PLoS genetics. [PubMed 21383967]
  3. Celiac disease
    Dubois ,et al. Nat Genet 2010, Multiple common variants for celiac disease influencing immune gene expression , Nature genetics 2010 42- 4 : 295-302. [PubMed 20190752]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: CD247
Diseases sorted by gene-association score: immunodeficiency 25* (968), t-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta* (202), t cell deficiency (23), cd3zeta deficiency (17), oligoarticular juvenile idiopathic arthritis* (14), rheumatoid factor-negative juvenile idiopathic arthritis* (9), skin conditions (8), hiv-1 (3), ovarian cancer, somatic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.89 RPKM in Whole Blood
Total median expression: 64.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.80145-0.295 Picture PostScript Text
3' UTR -372.351041-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021663 - CR3_zeta/IgE_Fc_rcpt_gamma
IPR003110 - Phos_immunorcpt_sig_ITAM
IPR024128 - T-cell_CD3_zeta/eta

Pfam Domains:
PF02189 - Immunoreceptor tyrosine-based activation motif
PF11628 - T-cell surface glycoprotein CD3 zeta chain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1TCE
- NMR MuPIT

1YGR
- X-ray MuPIT

2HAC
- NMR MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2OQ1 - X-ray MuPIT 3IK5 - X-ray 3IOZ - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P20963
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:1990782 protein tyrosine kinase binding

Biological Process:
GO:0002250 adaptive immune response
GO:0002376 immune system process
GO:0007166 cell surface receptor signaling pathway
GO:0016032 viral process
GO:0032623 interleukin-2 production
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0050690 regulation of defense response to virus by virus
GO:0050776 regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0051289 protein homotetramerization
GO:0070207 protein homotrimerization
GO:2000010 positive regulation of protein localization to cell surface

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex


-  Descriptions from all associated GenBank mRNAs
  AK128376 - Homo sapiens cDNA FLJ46519 fis, clone THYMU3033649, highly similar to T-cell surface glycoprotein CD3 zeta chain precursor.
BC025703 - Homo sapiens CD247 molecule, mRNA (cDNA clone MGC:34513 IMAGE:5222574), complete cds.
AK223325 - Homo sapiens mRNA for T-cell receptor zeta chain isoform 2 precursor variant, clone: TMS08236.
JD092289 - Sequence 73313 from Patent EP1572962.
JD456145 - Sequence 437169 from Patent EP1572962.
EF364118 - Homo sapiens isolate CG8F5Z CD3zeta chain (CD247) mRNA, 3' UTR.
J04132 - Human T cell receptor zeta-chain mRNA, complete cds.
JD103461 - Sequence 84485 from Patent EP1572962.
JD515163 - Sequence 496187 from Patent EP1572962.
JD473086 - Sequence 454110 from Patent EP1572962.
JD484529 - Sequence 465553 from Patent EP1572962.
JD469251 - Sequence 450275 from Patent EP1572962.
JD384055 - Sequence 365079 from Patent EP1572962.
JD185094 - Sequence 166118 from Patent EP1572962.
JD186604 - Sequence 167628 from Patent EP1572962.
JD445718 - Sequence 426742 from Patent EP1572962.
JD393550 - Sequence 374574 from Patent EP1572962.
JD247368 - Sequence 228392 from Patent EP1572962.
JD084278 - Sequence 65302 from Patent EP1572962.
JD369514 - Sequence 350538 from Patent EP1572962.
EF079882 - Homo sapiens CD247 mRNA, 3' UTR.
EF364117 - Homo sapiens isolate cr8F3Z CD3zeta chain (CD247) mRNA, 3' UTR.
JD440174 - Sequence 421198 from Patent EP1572962.
JD525622 - Sequence 506646 from Patent EP1572962.
JD252568 - Sequence 233592 from Patent EP1572962.
JD334492 - Sequence 315516 from Patent EP1572962.
JD382268 - Sequence 363292 from Patent EP1572962.
X55510 - H.sapiens (clone pBS NK1) CD3-zeta mRNA.
X55511 - H.sapiens (clone pBS NK2) CD3-zeta mRNA.
X55512 - H.sapiens (clone pBS NK3) CD3-zeta mRNA.
JD052662 - Sequence 33686 from Patent EP1572962.
EU597245 - Homo sapiens CD247 transcript variant 2 (CD247) mRNA, partial cds.
EU117371 - Homo sapiens isolate OC PBMC 01 CD247 (TCRZ) mRNA, partial cds.
EU117372 - Homo sapiens isolate OC PBMC 02 CD247 (TCRZ) mRNA, partial cds.
EU117373 - Homo sapiens isolate OC PBMC 03 CD247 (TCRZ) mRNA, partial cds.
EU118788 - Homo sapiens isolate HI PBMNC 01 TCR zeta chain (TCRZ) mRNA, partial cds.
EU118789 - Homo sapiens isolate HI PBMNC 02 TCR zeta chain (TCRZ) mRNA, partial cds.
EU118790 - Homo sapiens isolate HI PBMNC 03 TCR zeta chain (TCRZ) mRNA, partial cds.
EU118791 - Homo sapiens isolate OC TIL 01 TCR zeta chain (TCRZ) mRNA, partial cds.
EU118792 - Homo sapiens isolate OC TIL 02 TCR zeta chain (TCRZ) mRNA, partial cds.
EU118793 - Homo sapiens isolate OC TIL 03 TCR zeta chain (TCRZ) mRNA, partial cds.
AF228312 - Homo sapiens T-cell receptor zeta chain precursor, mRNA, partial cds.
AK313946 - Homo sapiens cDNA, FLJ94588, Homo sapiens CD3Z antigen, zeta polypeptide (TiT3 complex) (CD3Z), mRNA.
CU693020 - Synthetic construct Homo sapiens gateway clone IMAGE:100017947 5' read CD247 mRNA.
EU176191 - Synthetic construct Homo sapiens clone IMAGE:100006607; FLH264000.01X; RZPDo839E09245D CD247 molecule (CD247) gene, encodes complete protein.
KJ890852 - Synthetic construct Homo sapiens clone ccsbBroadEn_00246 CD247 gene, encodes complete protein.
DQ893778 - Synthetic construct Homo sapiens clone IMAGE:100008238; FLH167483.01L; RZPDo839B0489D CD247 molecule (CD247) gene, encodes complete protein.
AB590419 - Synthetic construct DNA, clone: pFN21AE1475, Homo sapiens CD247 gene for CD247 molecule, without stop codon, in Flexi system.
EF364119 - Homo sapiens isolate cr2F1Z CD3zeta chain (CD247) mRNA, partial cds.
JD387619 - Sequence 368643 from Patent EP1572962.
JD460156 - Sequence 441180 from Patent EP1572962.
JD414376 - Sequence 395400 from Patent EP1572962.
JD536632 - Sequence 517656 from Patent EP1572962.
JD129861 - Sequence 110885 from Patent EP1572962.
JD056295 - Sequence 37319 from Patent EP1572962.
JD209173 - Sequence 190197 from Patent EP1572962.
JD226615 - Sequence 207639 from Patent EP1572962.
JD209172 - Sequence 190196 from Patent EP1572962.
JD383058 - Sequence 364082 from Patent EP1572962.
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MA868508 - JP 2018536436-A/344: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868509 - JP 2018536436-A/345: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868510 - JP 2018536436-A/346: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868511 - JP 2018536436-A/347: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868541 - JP 2018536436-A/377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868542 - JP 2018536436-A/378: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868543 - JP 2018536436-A/379: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868544 - JP 2018536436-A/380: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868545 - JP 2018536436-A/381: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868546 - JP 2018536436-A/382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868547 - JP 2018536436-A/383: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868548 - JP 2018536436-A/384: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868549 - JP 2018536436-A/385: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868550 - JP 2018536436-A/386: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868551 - JP 2018536436-A/387: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868552 - JP 2018536436-A/388: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868553 - JP 2018536436-A/389: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868554 - JP 2018536436-A/390: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA868555 - JP 2018536436-A/391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590743 - KR 1020180133840-A/167: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590750 - KR 1020180133840-A/174: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590774 - KR 1020180133840-A/198: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590776 - KR 1020180133840-A/200: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590779 - KR 1020180133840-A/203: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590794 - KR 1020180133840-A/218: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590800 - KR 1020180133840-A/224: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590801 - KR 1020180133840-A/225: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590802 - KR 1020180133840-A/226: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590805 - KR 1020180133840-A/229: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590806 - KR 1020180133840-A/230: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590862 - KR 1020180133840-A/286: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590863 - KR 1020180133840-A/287: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590870 - KR 1020180133840-A/294: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590871 - KR 1020180133840-A/295: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590922 - KR 1020180133840-A/346: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590953 - KR 1020180133840-A/377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590954 - KR 1020180133840-A/378: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590955 - KR 1020180133840-A/379: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590956 - KR 1020180133840-A/380: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590957 - KR 1020180133840-A/381: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590958 - KR 1020180133840-A/382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590959 - KR 1020180133840-A/383: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590961 - KR 1020180133840-A/385: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590962 - KR 1020180133840-A/386: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590963 - KR 1020180133840-A/387: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590964 - KR 1020180133840-A/388: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY590966 - KR 1020180133840-A/390: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY590967 - KR 1020180133840-A/391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa05142 - Chagas disease

BioCarta from NCI Cancer Genome Anatomy Project
h_ctlPathway - CTL mediated immune response against target cells
h_tob1Pathway - Role of Tob in T-cell activation
h_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
h_tcrPathway - T Cell Receptor Signaling Pathway
h_tcrmolecule - T Cell Receptor and CD3 Complex
h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
h_thelperPathway - T Helper Cell Surface Molecules
h_ctla4Pathway - The Co-Stimulatory Signal During T-cell Activation
h_tcytotoxicPathway - T Cytotoxic Cell Surface Molecules
h_no2il12Pathway - NO2-dependent IL 12 Pathway in NK cells
h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents
h_il17Pathway - IL 17 Signaling Pathway
h_tcapoptosisPathway - HIV Induced T Cell Apoptosis
h_tcraPathway - Lck and Fyn tyrosine kinases in initiation of TCR Activation

Reactome (by CSHL, EBI, and GO)

Protein P20963 (Reactome details) participates in the following event(s):

R-HSA-164943 Nef mediated activation of the T-cell receptor
R-HSA-8850326 TCR binds self-lipid-based antigen via CD1
R-HSA-8850356 TCR binds microbial lipid-based antigen via CD1
R-HSA-198955 TCR complex interacts with peptide antigen-presenting MHC Class I
R-HSA-202214 Dephosphorylation of Lck-pY505 by CD45
R-HSA-202233 Inactivation of Lck by Csk
R-HSA-202291 Activation of Lck
R-HSA-8852200 Inactivation of LCK by PTPN22
R-HSA-202165 Phosphorylation of ITAM motifs in CD3 complexes
R-HSA-389758 Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
R-HSA-202168 Phosphorylation of ZAP-70 by Lck
R-HSA-202307 Change of PKC theta conformation
R-HSA-2029457 Cross-linking of FCGRIIIA with IgG-coated Ag
R-HSA-5685602 NCR3LG1 binds NCR3
R-HSA-6793275 CMVPP65 binds NCR3
R-HSA-5685600 viral HA binds NCRI
R-HSA-202344 Recruitment of ZAP-70 to phosphorylated ITAMs
R-HSA-202174 Activation of ZAP-70
R-HSA-8855381 PTPN22 dephosphorylates ZAP70
R-HSA-202216 Phosphorylation of SLP-76
R-HSA-202245 Phosphorylation of TBSMs in LAT
R-HSA-2029452 Recruitment of SYK to phosphorylated ITAMs
R-HSA-202248 Phosphorylation of PLC-gamma1
R-HSA-2029449 Phosphorylation of SYK by Src kinases
R-HSA-2029270 Recruitment of PLCgamma to membrane
R-HSA-2029273 PI3K binds to p-6Y-SYK
R-HSA-2029458 Recruitment of VAV1 to p-6Y-SYK
R-HSA-2197697 Recruitment of CRKII:DOCK180:ELMO complex to FCGR
R-HSA-2029272 Release of PLCG from FCGR
R-HSA-2029453 Phosphorylation of VAV
R-HSA-2029268 Phosphorylation and activation of PLCG
R-HSA-2029467 Activation of RAC1 by CRKII:DOCK180:ELMO
R-HSA-2029451 Activation of RAC1 by VAV
R-HSA-2029271 PI3K phosphorylates PIP2 to PIP3
R-HSA-164944 Nef and signal transduction
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-1280218 Adaptive Immune System
R-HSA-389948 PD-1 signaling
R-HSA-162909 Host Interactions of HIV factors
R-HSA-202403 TCR signaling
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202424 Downstream TCR signaling
R-HSA-168256 Immune System
R-HSA-388841 Costimulation by the CD28 family
R-HSA-2029481 FCGR activation
R-HSA-162906 HIV Infection
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-5663205 Infectious disease
R-HSA-168249 Innate Immune System
R-HSA-1643685 Disease
R-HSA-202433 Generation of second messenger molecules
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis

-  Other Names for This Gene
  Alternate Gene Symbols: B1AK49, CD3Z, CD3Z_HUMAN, NM_198053, NP_932170, P20963, Q5VX13, Q8TAX4, T3Z, TCRZ
UCSC ID: uc001gei.4
RefSeq Accession: NM_198053
Protein: P20963 (aka CD3Z_HUMAN)
CCDS: CCDS1260.1, CCDS1261.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198053.2
exon count: 8CDS single in 3' UTR: no RNA size: 1690
ORF size: 495CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 1190.00frame shift in genome: no % Coverage: 99.47
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.