Human Gene FCRL2 (uc001fre.2) Description and Page Index
Description: Homo sapiens Fc receptor-like 2 (FCRL2), mRNA. RefSeq Summary (NM_030764): This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]. Transcript (Including UTRs) Position: hg19 chr1:157,715,523-157,746,922 Size: 31,400 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr1:157,716,526-157,746,863 Size: 30,338 Coding Exon Count: 12
ID:FCRL2_HUMAN DESCRIPTION: RecName: Full=Fc receptor-like protein 2; Short=FcR-like protein 2; Short=FcRL2; AltName: Full=Fc receptor homolog 2; Short=FcRH2; AltName: Full=IFGP family protein 4; AltName: Full=Immunoglobulin receptor translocation-associated protein 4; AltName: Full=SH2 domain-containing phosphatase anchor protein 1; AltName: CD_antigen=CD307b; Flags: Precursor; FUNCTION: May have an regulatory role in normal and neoplastic B cell development. SUBUNIT: The tyrosine-phosphorylated isoform 2 interacts with PTPN6. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B- cell lines. Preferentially expressed in memory B-cells (at protein level). DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6. PTM: Isoform 2 is N- and O-glycosylated, and phosphorylated. SIMILARITY: Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): FCRL2 CDC HuGE Published Literature: FCRL2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96LA5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.