Description: Homo sapiens zinc finger protein 259 (ZPR1), mRNA. RefSeq Summary (NM_003904): The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]. Transcript (Including UTRs) Position: hg19 chr11:116,649,276-116,658,739 Size: 9,464 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr11:116,649,641-116,658,706 Size: 9,066 Coding Exon Count: 14
ID:ZPR1_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein ZPR1; AltName: Full=Zinc finger protein 259; FUNCTION: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus. SUBUNIT: Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Translocates to the nucleolus after treatment with mitogens. SIMILARITY: Belongs to the ZPR1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75312
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0001833 inner cell mass cell proliferation GO:0001834 trophectodermal cell proliferation GO:0006397 mRNA processing GO:0007165 signal transduction GO:0008283 cell proliferation GO:0008380 RNA splicing GO:0010628 positive regulation of gene expression GO:0021510 spinal cord development GO:0030154 cell differentiation GO:0030576 Cajal body organization GO:0031641 regulation of myelination GO:0033120 positive regulation of RNA splicing GO:0042023 DNA endoreduplication GO:0042307 positive regulation of protein import into nucleus GO:0045927 positive regulation of growth GO:0061564 axon development GO:0071364 cellular response to epidermal growth factor stimulus GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle GO:1902742 apoptotic process involved in development GO:1990261 pre-mRNA catabolic process GO:2000672 negative regulation of motor neuron apoptotic process
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