Description: Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA. RefSeq Summary (NM_004218): The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr19:8,455,205-8,469,317 Size: 14,113 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr19:8,455,301-8,468,442 Size: 13,142 Coding Exon Count: 5
ID:RB11B_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-11B; AltName: Full=GTP-binding protein YPT3; Flags: Precursor; FUNCTION: GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity). SUBUNIT: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RAB11B CDC HuGE Published Literature: RAB11B Positive Disease Associations: Cholesterol, HDL Related Studies:
Cholesterol, HDL Sekar Kathiresan et al. Nature genetics 2009, Common variants at 30 loci contribute to polygenic dyslipidemia., Nature genetics.
[PubMed 19060906]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15907
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001881 receptor recycling GO:0015031 protein transport GO:0032402 melanosome transport GO:0033572 transferrin transport GO:0035773 insulin secretion involved in cellular response to glucose stimulus GO:0043687 post-translational protein modification GO:0044070 regulation of anion transport GO:0045054 constitutive secretory pathway GO:0045055 regulated exocytosis GO:0045056 transcytosis GO:0071468 cellular response to acidic pH GO:0090150 establishment of protein localization to membrane GO:1990126 retrograde transport, endosome to plasma membrane GO:2000008 regulation of protein localization to cell surface GO:2001135 regulation of endocytic recycling
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
