Human Gene VSTM2A (uc010kzf.3)
Description: Homo sapiens V-set and transmembrane domain containing 2A (VSTM2A), mRNA.
Transcript (Including UTRs)
Position: hg19 chr7:54,610,019-54,636,948 Size: 26,930 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr7:54,610,424-54,636,778 Size: 26,355 Coding Exon Count: 5
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: VTM2A_HUMAN
DESCRIPTION: RecName: Full=V-set and transmembrane domain-containing protein 2A; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.SEQUENCE CAUTION: Sequence=AAH28404.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAL23809.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
C548651
2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
D013749
Tetrachlorodibenzodioxin
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
Pfam Domains: PF00047 - Immunoglobulin domain
PF07679 - Immunoglobulin I-set domain
PF07686 - Immunoglobulin V-set domain
PF13927 - Immunoglobulin domain
SCOP Domains: 48726 - Immunoglobulin
ModBase Predicted Comparative 3D Structure on Q8TAG5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC028404 - Homo sapiens V-set and transmembrane domain containing 2A, mRNA (cDNA clone MGC:33530 IMAGE:4820705), complete cds.JD063802 - Sequence 44826 from Patent EP1572962.JD437911 - Sequence 418935 from Patent EP1572962.JD368499 - Sequence 349523 from Patent EP1572962.JD517757 - Sequence 498781 from Patent EP1572962.JD258048 - Sequence 239072 from Patent EP1572962.JD516770 - Sequence 497794 from Patent EP1572962.JD405634 - Sequence 386658 from Patent EP1572962.CU688494 - Synthetic construct Homo sapiens gateway clone IMAGE:100023459 5' read VSTM2A mRNA.HQ448214 - Synthetic construct Homo sapiens clone IMAGE:100071613; CCSB001780_01 V-set and transmembrane domain containing 2 (VSTM2A) gene, encodes complete protein.KJ904037 - Synthetic construct Homo sapiens clone ccsbBroadEn_13431 VSTM2A gene, encodes complete protein.
Other Names for This Gene
Alternate Gene Symbols: A4D2E9, B5MC94, NM_182546, NP_872352, Q8TAG5, VSTM2, VTM2A_HUMANUCSC ID: uc010kzf.3RefSeq Accession: NM_182546
Protein: Q8TAG5
(aka VTM2A_HUMAN)
CCDS: CCDS5512.2
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_182546.2
exon count:
5 CDS single in 3' UTR:
no
RNA size:
1286
ORF size:
711 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
1589.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.