Description: Homo sapiens diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2), transcript variant 2, mRNA. RefSeq Summary (NM_015216): This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016]. Transcript (Including UTRs) Position: hg19 chr5:102,465,010-102,539,224 Size: 74,215 Total Exon Count: 29 Strand: + Coding Region Position: hg19 chr5:102,465,294-102,537,335 Size: 72,042 Coding Exon Count: 29
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43314-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein O43314 (Reactome details) participates in the following event(s):
R-HSA-1855216 IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol R-HSA-1855182 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol R-HSA-1855167 Synthesis of pyrophosphates in the cytosol R-HSA-1483249 Inositol phosphate metabolism R-HSA-1430728 Metabolism
US Server
