Human Gene ZNF503 (uc001jxg.3)
  Description: Homo sapiens zinc finger protein 503 (ZNF503), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:77,157,603-77,161,513 Size: 3,911 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr10:77,158,507-77,161,177 Size: 2,671 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:77,157,603-77,161,513)mRNA (may differ from genome)Protein (646 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN503_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 503;
FUNCTION: May function as a transcriptional repressor (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the Elbow/Noc family.
SIMILARITY: Contains 1 C2H2-type zinc finger.
SEQUENCE CAUTION: Sequence=BAC03999.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.58 RPKM in Ovary
Total median expression: 647.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -183.80336-0.547 Picture PostScript Text
3' UTR -247.24904-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022129 - Tscrpt_rep_NocA-like
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF12402 - NocA-like zinc-finger protein 1

ModBase Predicted Comparative 3D Structure on Q96F45
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsemblFlyBase  
 Protein SequenceProtein SequenceProtein Sequence  
 AlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0010629 negative regulation of gene expression
GO:0061351 neural precursor cell proliferation
GO:0070315 G1 to G0 transition involved in cell differentiation

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK092897 - Homo sapiens cDNA FLJ35578 fis, clone SPLEN2006325, weakly similar to Zinc finger protein nocA.
AX747796 - Sequence 1321 from Patent EP1308459.
BC011625 - Homo sapiens zinc finger protein 503, mRNA (cDNA clone MGC:10743 IMAGE:4053098), complete cds.
BC013011 - Homo sapiens zinc finger protein 503, mRNA (cDNA clone MGC:4159 IMAGE:3604473), complete cds.
BC021165 - Homo sapiens zinc finger protein 503, mRNA (cDNA clone MGC:16268 IMAGE:3830632), complete cds.
BC007494 - Homo sapiens zinc finger protein 503, mRNA (cDNA clone IMAGE:2967616), complete cds.
AK127647 - Homo sapiens cDNA FLJ45745 fis, clone KIDNE2018268, highly similar to Homo sapiens zinc finger protein 503 (ZNF503), mRNA.
AK290311 - Homo sapiens cDNA FLJ76083 complete cds, highly similar to Homo sapiens zinc finger protein 503 (ZNF503), mRNA.
JD416167 - Sequence 397191 from Patent EP1572962.
JD180001 - Sequence 161025 from Patent EP1572962.
JD178555 - Sequence 159579 from Patent EP1572962.
AK225851 - Homo sapiens mRNA for zinc finger protein 503 variant, clone: FCC125G11.
JD215716 - Sequence 196740 from Patent EP1572962.
JD340304 - Sequence 321328 from Patent EP1572962.
JD343099 - Sequence 324123 from Patent EP1572962.
JD460868 - Sequence 441892 from Patent EP1572962.
JD460758 - Sequence 441782 from Patent EP1572962.
JD217367 - Sequence 198391 from Patent EP1572962.
EU446545 - Synthetic construct Homo sapiens clone IMAGE:100070107; IMAGE:100011754; FLH257444.01L zinc finger protein 503 (ZNF503) gene, encodes complete protein.
KJ899833 - Synthetic construct Homo sapiens clone ccsbBroadEn_09227 ZNF503 gene, encodes complete protein.
KJ906375 - Synthetic construct Homo sapiens clone ccsbBroadEn_16045 ZNF503 gene, encodes complete protein.
CU680472 - Synthetic construct Homo sapiens gateway clone IMAGE:100017427 5' read ZNF503 mRNA.
LF212561 - JP 2014500723-A/20064: Polycomb-Associated Non-Coding RNAs.
MA448138 - JP 2018138019-A/20064: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_032772, NP_116161, Q8NAC5, Q96E25, Q96F45, Q96IJ0, ZN503_HUMAN
UCSC ID: uc001jxg.3
RefSeq Accession: NM_032772
Protein: Q96F45 (aka ZN503_HUMAN)
CCDS: CCDS7350.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032772.4
exon count: 2CDS single in 3' UTR: no RNA size: 3198
ORF size: 1941CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4067.50frame shift in genome: no % Coverage: 99.47
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.