Human Gene ZNF791 (uc002mua.2)
  Description: Homo sapiens zinc finger protein 791 (ZNF791), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:12,721,732-12,740,676 Size: 18,945 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr19:12,721,894-12,740,074 Size: 18,181 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:12,721,732-12,740,676)mRNA (may differ from genome)Protein (576 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
ReactomeTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN791_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 791;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 17 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF791
CDC HuGE Published Literature: ZNF791

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D019327 Copper Sulfate
  • D004040 Dietary Carbohydrates
  • C006780 bisphenol A
  • C045651 epigallocatechin gallate
  • C027373 potassium chromate(VI)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.08 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 228.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.30162-0.341 Picture PostScript Text
3' UTR -171.20602-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q3KP31
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK307775 - Homo sapiens cDNA, FLJ97723.
AK298597 - Homo sapiens cDNA FLJ50832 complete cds, moderately similar to Zinc finger protein 709.
AX721060 - Sequence 20 from Patent WO0220754.
AK074877 - Homo sapiens cDNA FLJ90396 fis, clone NT2RP2005774, moderately similar to Homo sapiens GIOT-4 mRNA for gonadotropin inducible transcription repressor-4.
AK297715 - Homo sapiens cDNA FLJ52336 complete cds, moderately similar to Zinc finger protein 709.
BC106937 - Homo sapiens zinc finger protein 791, mRNA (cDNA clone MGC:126179 IMAGE:40033817), complete cds.
BC106938 - Homo sapiens zinc finger protein 791, mRNA (cDNA clone MGC:126180 IMAGE:40033819), complete cds.
EU446588 - Synthetic construct Homo sapiens clone IMAGE:100069973; IMAGE:100011797; FLH257063.01L zinc finger protein 791 (ZNF791) gene, encodes complete protein.
KJ895729 - Synthetic construct Homo sapiens clone ccsbBroadEn_05123 ZNF791 gene, encodes complete protein.
JD314814 - Sequence 295838 from Patent EP1572962.
JD314815 - Sequence 295839 from Patent EP1572962.
AL832869 - Homo sapiens mRNA; cDNA DKFZp667E083 (from clone DKFZp667E083).
JD314816 - Sequence 295840 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
AF006199 - Homo sapiens leukemia susceptibility mRNA, 3' region.
AF035364 - Homo sapiens apoptosis-related mRNA, 3'UTR, partial sequence.
JD079223 - Sequence 60247 from Patent EP1572962.
JD408532 - Sequence 389556 from Patent EP1572962.
JD511629 - Sequence 492653 from Patent EP1572962.
JD376326 - Sequence 357350 from Patent EP1572962.
JD542370 - Sequence 523394 from Patent EP1572962.
JD211832 - Sequence 192856 from Patent EP1572962.
JD452686 - Sequence 433710 from Patent EP1572962.
JD440860 - Sequence 421884 from Patent EP1572962.
JD338555 - Sequence 319579 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q3KP31 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_153358, NP_699189, Q3KP31, Q8NC99, ZN791_HUMAN
UCSC ID: uc002mua.2
RefSeq Accession: NM_153358
Protein: Q3KP31 (aka ZN791_HUMAN)
CCDS: CCDS12273.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_153358.2
exon count: 4CDS single in 3' UTR: no RNA size: 2495
ORF size: 1731CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3599.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.