Human Gene SPNS1 (uc010vdi.1) Description and Page Index
Description: Homo sapiens spinster homolog 1 (Drosophila) (SPNS1), transcript variant 2, mRNA.
Transcript (Including UTRs)
Position: hg19 chr16:28,986,096-28,996,838 Size: 10,743 Total Exon Count: 13 Strand: +
Position: hg19 chr16:28,986,473-28,995,620 Size: 9,148 Coding Exon Count: 12
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein spinster homolog 1; AltName: Full=HSpin1; AltName: Full=Spinster-like protein 1;
FUNCTION: Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death. SUBUNIT: Interacts with BCL2 and BCL2L1. INTERACTION: Q07817:BCL2L1; NbExp=3; IntAct=EBI-1386527, EBI-78035; SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. Note=Colocalizes with SDHB. SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily. Spinster (TC 2.A.1.49) family. SEQUENCE CAUTION: Sequence=AAQ15259.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAQ15259.1; Type=Frameshift; Positions=97;
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011701 - MFS
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
Pfam Domains: PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on Q9H2V7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC038961 - Homo sapiens spinster homolog 1 (Drosophila), mRNA (cDNA clone MGC:47562 IMAGE:6053095), complete cds. AK095677 - Homo sapiens cDNA FLJ38358 fis, clone FEBRA2000210. AK289787 - Homo sapiens cDNA FLJ78727 complete cds. BC065235 - Homo sapiens spinster homolog 1 (Drosophila), mRNA (cDNA clone MGC:70841 IMAGE:6161778), complete cds. AF370423 - Homo sapiens PP2030 mRNA, complete cds. BC047741 - Homo sapiens spinster homolog 1 (Drosophila), mRNA (cDNA clone MGC:54108 IMAGE:5757339), complete cds. AB209402 - Homo sapiens mRNA for spinster variant protein. AL390215 - Homo sapiens mRNA; cDNA DKFZp727E151 (from clone DKFZp727E151). AF212371 - Homo sapiens spinster-like protein mRNA, complete cds. BC008325 - Homo sapiens spinster homolog 1 (Drosophila), mRNA (cDNA clone MGC:15767 IMAGE:3501826), complete cds. AM392778 - Synthetic construct Homo sapiens clone IMAGE:100002393 for hypothetical protein (SPIN1 gene). AM393748 - Synthetic construct Homo sapiens clone IMAGE:100002431 for hypothetical protein (SPIN1 gene). AB528362 - Synthetic construct DNA, clone: pF1KB0485, Homo sapiens SPNS1 gene for spinster homolog 1, without stop codon, in Flexi system. CU678917 - Synthetic construct Homo sapiens gateway clone IMAGE:100017390 5' read SPNS1 mRNA. KJ899746 - Synthetic construct Homo sapiens clone ccsbBroadEn_09140 SPNS1 gene, encodes complete protein. BC006156 - Homo sapiens spinster homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:3627317), partial cds. JD477441 - Sequence 458465 from Patent EP1572962. JD525102 - Sequence 506126 from Patent EP1572962. BC011563 - Homo sapiens linker for activation of T cells, mRNA (cDNA clone MGC:20145 IMAGE:4644259), complete cds. AK307342 - Homo sapiens cDNA, FLJ97290. AJ223280 - Homo sapiens mRNA for tyrosine-phosphorylated protein of 36 kD (pp36) (LAT gene). AF036906 - Homo sapiens linker for activation of T cells (LAT) mRNA, alternatively spliced form, complete cds. JD477729 - Sequence 458753 from Patent EP1572962. AF036905 - Homo sapiens linker for activation of T cells (LAT) mRNA, complete cds. JD221795 - Sequence 202819 from Patent EP1572962. KJ893590 - Synthetic construct Homo sapiens clone ccsbBroadEn_02984 LAT gene, encodes complete protein. FN432831 - Homo sapiens mRNA for linker for activation of T-cells family member 1 (LAT gene), transcript variant Ins27. FN432832 - Homo sapiens mRNA for linker for activation of T-cells family member 1 (LAT gene), transcript variant Del3. FN432833 - Homo sapiens mRNA for linker for activation of T-cells family member 1 (LAT gene), transcript variant Del30. FN432834 - Homo sapiens mRNA for linker for activation of T-cells family member 1 (LAT gene), transcript variant Del116. JD027469 - Sequence 8493 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: B5MDM9, NM_001142448, NP_001135922, PP20300, Q6P182, Q71RB5, Q7L541, Q86VU7, Q8N953, Q8TCS5, Q9BRN5, Q9H2V7, SPIN1, SPNS1_HUMAN UCSC ID: uc010vdi.1 RefSeq Accession: NM_001142448
(aka SPNS1_HUMAN) Q9H2V7
Gene Model Information
13 CDS single in 3' UTR:
1587 CDS single in intron:
Alignment % ID:
3544.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.