Human Gene WDR46 (uc003ods.3) Description and Page Index
Description: Homo sapiens WD repeat domain 46 (WDR46), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr6:33,246,880-33,257,304 Size: 10,425 Total Exon Count: 15 Strand: -
Position: hg19 chr6:33,247,053-33,256,947 Size: 9,895 Coding Exon Count: 15
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=WD repeat-containing protein 46; AltName: Full=WD repeat-containing protein BING4;
SIMILARITY: Contains 6 WD repeats.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
WDR46 CDC HuGE Published Literature:
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR012952 - BING4_C_dom
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom
Pfam Domains: PF00400 - WD domain, G-beta repeat
PF08149 - BING4CT (NUC141) domain
SCOP Domains: 50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain
ModBase Predicted Comparative 3D Structure on O15213
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC000388 - Homo sapiens WD repeat domain 46, mRNA (cDNA clone MGC:8435 IMAGE:2821198), complete cds. AF447870 - Homo sapiens FP221 mRNA, complete cds. AK297925 - Homo sapiens cDNA FLJ51004 complete cds, highly similar to WD repeat protein 46. AK292616 - Homo sapiens cDNA FLJ77639 complete cds. AK292171 - Homo sapiens cDNA FLJ77705 complete cds. JD222501 - Sequence 203525 from Patent EP1572962. JD203161 - Sequence 184185 from Patent EP1572962. JD539121 - Sequence 520145 from Patent EP1572962. JD555091 - Sequence 536115 from Patent EP1572962. JD305229 - Sequence 286253 from Patent EP1572962. JD323217 - Sequence 304241 from Patent EP1572962. AK298151 - Homo sapiens cDNA FLJ51014 complete cds, highly similar to WD repeat protein 46. JD221069 - Sequence 202093 from Patent EP1572962. JD078187 - Sequence 59211 from Patent EP1572962. AK315616 - Homo sapiens cDNA, FLJ96697. KJ897991 - Synthetic construct Homo sapiens clone ccsbBroadEn_07385 WDR46 gene, encodes complete protein. AK311388 - Homo sapiens cDNA, FLJ18430. AK308534 - Homo sapiens cDNA, FLJ98575. CU674188 - Synthetic construct Homo sapiens gateway clone IMAGE:100017738 5' read WDR46 mRNA. JD460716 - Sequence 441740 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein O15213 ( Reactome details) participates in the following event(s): R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA
Other Names for This Gene
Alternate Gene Symbols: A6NDP5, BING4, C6orf11, FP221, NM_005452, NP_005443, O15213, Q5HYZ0, Q5STK5, Q5STR3, WDR46_HUMAN UCSC ID: uc003ods.3 RefSeq Accession: NM_005452
(aka WDR46_HUMAN) O15213
Gene Model Information
15 CDS single in 3' UTR:
1833 CDS single in intron:
Alignment % ID:
3607.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.