Description: Homo sapiens exocyst complex component 3 (EXOC3), mRNA. RefSeq Summary (NM_007277): The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr5:443,334-467,409 Size: 24,076 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr5:446,321-467,013 Size: 20,693 Coding Exon Count: 12
ID:EXOC3_HUMAN DESCRIPTION: RecName: Full=Exocyst complex component 3; AltName: Full=Exocyst complex component Sec6; FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity). SIMILARITY: Belongs to the SEC6 family. SEQUENCE CAUTION: Sequence=BAB84912.1; Type=Frameshift; Positions=1, 563;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60645
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.