Human Gene THAP7 (uc002ztr.1) Description and Page Index
  Description: Homo sapiens THAP domain containing 7 (THAP7), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:21,354,061-21,356,404 Size: 2,344 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr22:21,354,169-21,356,200 Size: 2,032 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr22:21,354,061-21,356,404)mRNA (may differ from genome)Protein (309 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=THAP domain-containing protein 7;
FUNCTION: Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.
SUBUNIT: Interacts with HDAC3 and nuclear hormone receptor corepressors.
SUBCELLULAR LOCATION: Nucleus. Chromosome.
SIMILARITY: Contains 1 THAP-type zinc finger.

-  MalaCards Disease Associations
  MalaCards Gene Search: THAP7
Diseases sorted by gene-association score: exstrophy of bladder (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.55 RPKM in Pituitary
Total median expression: 848.77 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3030-0.243 Picture PostScript Text
3' UTR -33.20108-0.307 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026519 - THAP7
IPR006612 - Znf_C2CH

Pfam Domains:
PF05485 - THAP domain

ModBase Predicted Comparative 3D Structure on Q9BT49
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0070742 C2H2 zinc finger domain binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045892 negative regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005694 chromosome
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle

-  Descriptions from all associated GenBank mRNAs
  EU832669 - Synthetic construct Homo sapiens clone HAIB:100067698; DKFZo008H0231 THAP domain containing 7 protein (THAP7) gene, encodes complete protein.
EU832748 - Synthetic construct Homo sapiens clone HAIB:100067777; DKFZo004H0232 THAP domain containing 7 protein (THAP7) gene, encodes complete protein.
BC004346 - Homo sapiens THAP domain containing 7, mRNA (cDNA clone MGC:10963 IMAGE:3633743), complete cds.
AK025906 - Homo sapiens cDNA: FLJ22253 fis, clone HRC02763.
AK024609 - Homo sapiens cDNA: FLJ20956 fis, clone ADSE02049.
AK300715 - Homo sapiens cDNA FLJ54841 complete cds, highly similar to THAP domain-containing protein 7.
CR456343 - Homo sapiens Em:AC002472.8 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.Em:AC002472.8).
JD070791 - Sequence 51815 from Patent EP1572962.
JD156229 - Sequence 137253 from Patent EP1572962.
CU013054 - Homo sapiens THAP7, mRNA (cDNA clone IMAGE:100000312), complete cds, with stop codon, in Gateway system.
AK315457 - Homo sapiens cDNA, FLJ96515, highly similar to Homo sapiens THAP domain containing 7 (THAP7), mRNA.
KJ899653 - Synthetic construct Homo sapiens clone ccsbBroadEn_09047 THAP7 gene, encodes complete protein.
AB528250 - Synthetic construct DNA, clone: pF1KE0517, Homo sapiens THAP7 gene for THAP domain containing 7, without stop codon, in Flexi system.
CU013342 - Homo sapiens THAP7, mRNA (cDNA clone IMAGE:100000216), complete cds, without stop codon, in Gateway system.
CU678674 - Synthetic construct Homo sapiens gateway clone IMAGE:100018823 5' read THAP7 mRNA.
DQ580300 - Homo sapiens piRNA piR-48412, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD97, D3DX40, NM_001008695, NP_085050, Q9BT49, THAP7_HUMAN
UCSC ID: uc002ztr.1
RefSeq Accession: NM_001008695
Protein: Q9BT49 (aka THAP7_HUMAN or THA7_HUMAN)
CCDS: CCDS13787.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001008695.1
exon count: 5CDS single in 3' UTR: no RNA size: 1097
ORF size: 930CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2049.00frame shift in genome: no % Coverage: 97.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.