Human Gene PRR14 (uc002dyy.3) Description and Page Index
  Description: Homo sapiens proline rich 14 (PRR14), mRNA.
RefSeq Summary (NM_024031): The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016].
Transcript (Including UTRs)
   Position: hg19 chr16:30,662,241-30,667,734 Size: 5,494 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr16:30,662,967-30,667,632 Size: 4,666 Coding Exon Count: 11 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:30,662,241-30,667,734)mRNA (may differ from genome)Protein (585 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.98 RPKM in Brain - Cerebellum
Total median expression: 914.21 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -122.00258-0.473 Picture PostScript Text
3' UTR -15.30102-0.150 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026320 - PRR14

Pfam Domains:
PF15386 - Drosophila Tantalus-like

ModBase Predicted Comparative 3D Structure on Q9BWN1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007517 muscle organ development

Cellular Component:
GO:0005634 nucleus
GO:0005652 nuclear lamina
GO:0005654 nucleoplasm
GO:0005694 chromosome

-  Descriptions from all associated GenBank mRNAs
  CR936781 - Homo sapiens mRNA; cDNA DKFZp781A13198 (from clone DKFZp781A13198).
AK125716 - Homo sapiens cDNA FLJ43728 fis, clone TESOP2009555.
BC010232 - Homo sapiens proline rich 14, mRNA (cDNA clone IMAGE:3456487), partial cds.
BC050677 - Homo sapiens proline rich 14, mRNA (cDNA clone MGC:60225 IMAGE:6053861), complete cds.
BC011573 - Homo sapiens proline rich 14, mRNA (cDNA clone IMAGE:4619869), with apparent retained intron.
BC000119 - Homo sapiens proline rich 14, mRNA (cDNA clone MGC:3121 IMAGE:3351963), complete cds.
AK074783 - Homo sapiens cDNA FLJ90302 fis, clone NT2RP2000616, weakly similar to EXTENSIN PRECURSOR.
JD548304 - Sequence 529328 from Patent EP1572962.
BC021934 - Homo sapiens proline rich 14, mRNA (cDNA clone MGC:32116 IMAGE:4876482), complete cds.
DQ896090 - Synthetic construct Homo sapiens clone IMAGE:100010550; FLH190218.01L; RZPDo839F1165D proline rich 14 (PRR14) gene, encodes complete protein.
DQ892844 - Synthetic construct clone IMAGE:100005474; FLH190222.01X; RZPDo839F1175D proline rich 14 (PRR14) gene, encodes complete protein.
CU674048 - Synthetic construct Homo sapiens gateway clone IMAGE:100017718 5' read PRR14 mRNA.
KJ894621 - Synthetic construct Homo sapiens clone ccsbBroadEn_04015 PRR14 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_024031, NP_076936, PRR14_HUMAN, Q8WTX2, Q9BWN1
UCSC ID: uc002dyy.3
RefSeq Accession: NM_024031
Protein: Q9BWN1 (aka PRR14_HUMAN)
CCDS: CCDS10687.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_024031.2
exon count: 12CDS single in 3' UTR: no RNA size: 2154
ORF size: 1758CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3257.00frame shift in genome: no % Coverage: 98.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.