Human Gene METTL3 (uc001wbc.3) Description and Page Index
Description: Homo sapiens methyltransferase like 3 (METTL3), mRNA. RefSeq Summary (NM_019852): This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.114137.1, SRR1163655.125585.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298717.9/ ENSP00000298717.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr14:21,966,282-21,979,457 Size: 13,176 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr14:21,966,402-21,979,365 Size: 12,964 Coding Exon Count: 11
ID:MTA70_HUMAN DESCRIPTION: RecName: Full=N6-adenosine-methyltransferase 70 kDa subunit; Short=MT-A70; EC=220.127.116.11; AltName: Full=Methyltransferase-like protein 3; FUNCTION: N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + m(7)G(5')pppAm = S- adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. SUBCELLULAR LOCATION: Nucleus speckle. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components. TISSUE SPECIFICITY: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the MT-A70-like family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): METTL3 CDC HuGE Published Literature: METTL3 Positive Disease Associations: Uric Acid Related Studies:
Uric Acid Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics.
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86U44
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.