Human Gene ZSWIM8 (uc001jvj.3) Description and Page Index
  Description: Homo sapiens zinc finger, SWIM-type containing 8 (ZSWIM8), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:75,545,382-75,561,556 Size: 16,175 Total Exon Count: 26 Strand: +
Coding Region
   Position: hg19 chr10:75,545,637-75,561,534 Size: 15,898 Coding Exon Count: 26 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:75,545,382-75,561,556)mRNA (may differ from genome)Protein (1892 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIPubMedReactome
Stanford SOURCETreefamUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.05 RPKM in Pituitary
Total median expression: 897.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -129.00255-0.506 Picture PostScript Text
3' UTR 0.00220.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF04434 - SWIM zinc finger

ModBase Predicted Comparative 3D Structure on A7E2V4-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK091621 - Homo sapiens cDNA FLJ34302 fis, clone FEBRA2007620.
AX747098 - Sequence 623 from Patent EP1308459.
AB020720 - Homo sapiens KIAA0913 mRNA for KIAA0913 protein, partial cds.
BC137249 - Homo sapiens KIAA0913, mRNA (cDNA clone IMAGE:9021246), complete cds.
BC137250 - Homo sapiens KIAA0913, mRNA (cDNA clone IMAGE:9021247), complete cds.
BC151206 - Homo sapiens KIAA0913, mRNA (cDNA clone MGC:164743 IMAGE:40147119), complete cds.
AB384542 - Synthetic construct DNA, clone: pF1KA0913, Homo sapiens KIAA0913 gene for KIAA0913 protein, complete cds, without stop codon, in Flexi system.
BC156550 - Synthetic construct Homo sapiens clone IMAGE:100063206, MGC:190716 KIAA0913 (KIAA0913) mRNA, encodes complete protein.
JD262786 - Sequence 243810 from Patent EP1572962.
JD167044 - Sequence 148068 from Patent EP1572962.
JD525550 - Sequence 506574 from Patent EP1572962.
JD066388 - Sequence 47412 from Patent EP1572962.
AL133662 - Homo sapiens mRNA; cDNA DKFZp434E0121 (from clone DKFZp434E0121).
BC111006 - Homo sapiens KIAA0913, mRNA (cDNA clone IMAGE:5743924), partial cds.
AK023742 - Homo sapiens cDNA FLJ13680 fis, clone PLACE2000007, highly similar to Homo sapiens mRNA for KIAA0913 protein.
BC117205 - Homo sapiens KIAA0913, mRNA (cDNA clone IMAGE:40125756), partial cds.
JD062669 - Sequence 43693 from Patent EP1572962.
JD205440 - Sequence 186464 from Patent EP1572962.
BC040726 - Homo sapiens KIAA0913, mRNA (cDNA clone IMAGE:6155781), partial cds.
AK309136 - Homo sapiens cDNA, FLJ99177.
BC036835 - Homo sapiens KIAA0913, mRNA (cDNA clone IMAGE:4914657), partial cds.
BC063694 - Homo sapiens KIAA0913, mRNA (cDNA clone IMAGE:4748944), partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein A7E2V4 (Reactome details) participates in the following event(s):

R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-376176 Signaling by ROBO receptors
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A7E2V4-2, KIAA0913, NM_001242488, NP_001229417
UCSC ID: uc001jvj.3
RefSeq Accession: NM_001242488
Protein: A7E2V4-2, splice isoform of A7E2V4 CCDS: CCDS44440.1, CCDS60560.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001242488.1
exon count: 26CDS single in 3' UTR: no RNA size: 5970
ORF size: 5679CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 11558.00frame shift in genome: no % Coverage: 99.77
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.