Human Gene CDK11B (uc001agv.1)
Description: Homo sapiens cyclin-dependent kinase 11B (CDK11B), transcript variant 2, mRNA.
RefSeq Summary (NM_033486): This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Transcript (Including UTRs)
Position: hg19 chr1:1,571,100-1,655,775 Size: 84,676 Total Exon Count: 21 Strand: -
Coding Region
Position: hg19 chr1:1,571,126-1,654,257 Size: 83,132 Coding Exon Count: 20
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CDK11B
CDC HuGE Published Literature: CDK11B
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P21127-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Descriptions from all associated GenBank mRNAs
BC062579 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:5199576), partial cds.BC033069 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:3610222), **** WARNING: chimeric clone ****.AK000081 - Homo sapiens cDNA FLJ20074 fis, clone COL02336, highly similar to M37712 Human p58/GTA.U04815 - Human protein kinase PITSLRE alpha 1 mRNA, complete cds.AF067524 - Homo sapiens PITSLRE protein kinase beta SV12 isoform (CDC2L2) mRNA, complete cds.AF067512 - Homo sapiens PITSLRE protein kinase alpha SV1 isoform (CDC2L1) mRNA, complete cds.AF067513 - Homo sapiens PITSLRE protein kinase alpha SV4 isoform (CDC2L1) mRNA, complete cds.AF067514 - Homo sapiens PITSLRE protein kinase alpha SV5 isoform (CDC2L1) mRNA, complete cds.AF067515 - Homo sapiens PITSLRE protein kinase alpha SV9 isoform (CDC2L1) mRNA, complete cds.AF067516 - Homo sapiens PITSLRE protein kinase alpha SV10 isoform (CDC2L1) mRNA, complete cds.AF067517 - Homo sapiens PITSLRE protein kinase alpha SV11 isoform (CDC2L1) mRNA, complete cds.U04816 - Human protein kinase PITSLRE alpha 2-2 mRNA, complete cds.U04817 - Human protein kinase PITSLRE alpha 2-3 mRNA, complete cds.U04818 - Human protein kinase PITSLRE alpha 2-4 mRNA, complete cds.U04824 - Human protein kinase PITSLRE alpha 2-1 mRNA, complete cds.BC139777 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:40121212), partial cds.AK304679 - Homo sapiens cDNA FLJ59152 complete cds, highly similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).BC140714 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:176391 IMAGE:9021582), complete cds.BC171773 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:198488 IMAGE:9054427), complete cds.AF174497 - Homo sapiens GR AF-1 coactivator 3 mRNA, partial cds.JD412529 - Sequence 393553 from Patent EP1572962.JD395264 - Sequence 376288 from Patent EP1572962.JD125495 - Sequence 106519 from Patent EP1572962.JD022652 - Sequence 3676 from Patent EP1572962.JD029702 - Sequence 10726 from Patent EP1572962.JD345120 - Sequence 326144 from Patent EP1572962.JD292635 - Sequence 273659 from Patent EP1572962.AX033421 - Sequence 2 from Patent WO0044896.JD043805 - Sequence 24829 from Patent EP1572962.JD468561 - Sequence 449585 from Patent EP1572962.JD073738 - Sequence 54762 from Patent EP1572962.JD445039 - Sequence 426063 from Patent EP1572962.JD065460 - Sequence 46484 from Patent EP1572962.JD043760 - Sequence 24784 from Patent EP1572962.JD436361 - Sequence 417385 from Patent EP1572962.JD468542 - Sequence 449566 from Patent EP1572962.JD471391 - Sequence 452415 from Patent EP1572962.JD468559 - Sequence 449583 from Patent EP1572962.JD073737 - Sequence 54761 from Patent EP1572962.JD471164 - Sequence 452188 from Patent EP1572962.JD340003 - Sequence 321027 from Patent EP1572962.JD178297 - Sequence 159321 from Patent EP1572962.JD471387 - Sequence 452411 from Patent EP1572962.JD248560 - Sequence 229584 from Patent EP1572962.JD057707 - Sequence 38731 from Patent EP1572962.BC009375 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4121554), partial cds.JD094062 - Sequence 75086 from Patent EP1572962.JD075744 - Sequence 56768 from Patent EP1572962.BC110905 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone MGC:131975 IMAGE:6151813), complete cds.AB209095 - Homo sapiens mRNA for cell division cycle 2-like 2 isoform 4 variant protein.AF067525 - Homo sapiens PITSLRE protein kinase beta SV13 isoform (CDC2L2) mRNA, complete cds.AF067518 - Homo sapiens PITSLRE protein kinase beta SV8 isoform (CDC2L2) mRNA, complete cds.AF067519 - Homo sapiens PITSLRE protein kinase beta SV1 isoform (CDC2L2) mRNA, complete cds.AF067520 - Homo sapiens PITSLRE protein kinase beta SV2 isoform (CDC2L2) mRNA, complete cds.AF067521 - Homo sapiens PITSLRE protein kinase beta SV3 isoform (CDC2L2) mRNA, complete cds.AF067522 - Homo sapiens PITSLRE protein kinase beta SV6 isoform (CDC2L2) mRNA, complete cds.AF067523 - Homo sapiens PITSLRE protein kinase beta SV7 isoform (CDC2L2) mRNA, complete cds.U07704 - Human protein kinase PITSLRE isoform PBETA21 (p58CDC2L1) mRNA, complete cds.U07705 - Human protein kinase PITSLRE isoform PBETA22 (p58CDC2L1) mRNA, complete cds.AK303451 - Homo sapiens cDNA FLJ56557 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22).AK303446 - Homo sapiens cDNA FLJ56415 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22).AK301495 - Homo sapiens cDNA FLJ55257 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L2 (EC 2.7.11.22).AK295607 - Homo sapiens cDNA FLJ59025 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).BC028187 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4397976), partial cds.BC009375 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4121554), partial cds.JD075744 - Sequence 56768 from Patent EP1572962.JD460770 - Sequence 441794 from Patent EP1572962.JD470779 - Sequence 451803 from Patent EP1572962.JD354471 - Sequence 335495 from Patent EP1572962.JD336811 - Sequence 317835 from Patent EP1572962.JD518370 - Sequence 499394 from Patent EP1572962.JD554198 - Sequence 535222 from Patent EP1572962.JD274488 - Sequence 255512 from Patent EP1572962.AF067527 - Homo sapiens PITSLRE protein kinase beta SV16 isoform (CDC2L2) mRNA, partial cds.AF067529 - Homo sapiens PITSLRE protein kinase beta SV18 isoform (CDC2L2) mRNA, partial cds.AF067526 - Homo sapiens PITSLRE protein kinase beta SV15 isoform (CDC2L2) mRNA, partial cds.AF067528 - Homo sapiens PITSLRE protein kinase beta SV17 isoform (CDC2L2) mRNA, partial cds.JD214789 - Sequence 195813 from Patent EP1572962.JD214788 - Sequence 195812 from Patent EP1572962.JD395312 - Sequence 376336 from Patent EP1572962.JD395313 - Sequence 376337 from Patent EP1572962.JD436764 - Sequence 417788 from Patent EP1572962.JD434633 - Sequence 415657 from Patent EP1572962.JD301979 - Sequence 283003 from Patent EP1572962.JD090259 - Sequence 71283 from Patent EP1572962.JD565542 - Sequence 546566 from Patent EP1572962.JD396426 - Sequence 377450 from Patent EP1572962.JD470936 - Sequence 451960 from Patent EP1572962.JD039352 - Sequence 20376 from Patent EP1572962.JD437278 - Sequence 418302 from Patent EP1572962.JD433874 - Sequence 414898 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: CDC2L1, CDK11, NM_033486, NP_277021, P21127-2, PITSLREA, PK58UCSC ID: uc001agv.1RefSeq Accession: NM_033486
Protein: P21127-2 , splice isoform of P21127
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_033486.1
exon count:
21 CDS single in 3' UTR:
no
RNA size:
2486
ORF size:
2343 CDS single in intron:
no
Alignment % ID:
99.51
txCdsPredict score:
4749.00 frame shift in genome:
no
% Coverage:
98.59
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
1
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.