Human Gene GPR108 (uc002mfp.3) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 108 (GPR108), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:6,729,925-6,737,633 Size: 7,709 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr19:6,730,323-6,737,587 Size: 7,265 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:6,729,925-6,737,633)mRNA (may differ from genome)Protein (543 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein GPR108; AltName: Full=Lung seven transmembrane receptor 2; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the LU7TM family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GPR108
CDC HuGE Published Literature: GPR108

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.90 RPKM in Whole Blood
Total median expression: 1135.47 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.5046-0.315 Picture PostScript Text
3' UTR -140.20398-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009637 - TM_rcpt_euk

Pfam Domains:
PF06814 - Lung seven transmembrane receptor

ModBase Predicted Comparative 3D Structure on Q9NPR9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  LF385212 - JP 2014500723-A/192715: Polycomb-Associated Non-Coding RNAs.
JD427847 - Sequence 408871 from Patent EP1572962.
BC007862 - Homo sapiens G protein-coupled receptor 108, mRNA (cDNA clone IMAGE:4301053), complete cds.
AK291968 - Homo sapiens cDNA FLJ75847 complete cds, highly similar to Homo sapiens G protein-coupled receptor 108 (GPR108), mRNA.
AL365404 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1703145.
AX775899 - Sequence 169 from Patent WO03048202.
JD054783 - Sequence 35807 from Patent EP1572962.
BC150657 - Homo sapiens G protein-coupled receptor 108, mRNA (cDNA clone MGC:183568 IMAGE:9057028), complete cds.
BC146909 - Homo sapiens G protein-coupled receptor 108, mRNA (cDNA clone MGC:182012 IMAGE:9056837), complete cds.
JD244205 - Sequence 225229 from Patent EP1572962.
JD317634 - Sequence 298658 from Patent EP1572962.
JD093984 - Sequence 75008 from Patent EP1572962.
JD123626 - Sequence 104650 from Patent EP1572962.
JD428014 - Sequence 409038 from Patent EP1572962.
KJ902920 - Synthetic construct Homo sapiens clone ccsbBroadEn_12314 GPR108 gene, encodes complete protein.
JD358163 - Sequence 339187 from Patent EP1572962.
JD059557 - Sequence 40581 from Patent EP1572962.
JD251195 - Sequence 232219 from Patent EP1572962.
JD224222 - Sequence 205246 from Patent EP1572962.
JD109213 - Sequence 90237 from Patent EP1572962.
JD456509 - Sequence 437533 from Patent EP1572962.
JD478841 - Sequence 459865 from Patent EP1572962.
JD318677 - Sequence 299701 from Patent EP1572962.
JD381925 - Sequence 362949 from Patent EP1572962.
JD297453 - Sequence 278477 from Patent EP1572962.
JD184373 - Sequence 165397 from Patent EP1572962.
JD399941 - Sequence 380965 from Patent EP1572962.
JD338439 - Sequence 319463 from Patent EP1572962.
JD466676 - Sequence 447700 from Patent EP1572962.
JD427214 - Sequence 408238 from Patent EP1572962.
JD165047 - Sequence 146071 from Patent EP1572962.
MA620789 - JP 2018138019-A/192715: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B9EJD7, GP108_HUMAN, LUSTR2, NM_001080452, NP_001073921, Q9NPR9
UCSC ID: uc002mfp.3
RefSeq Accession: NM_001080452
Protein: Q9NPR9 (aka GP108_HUMAN)
CCDS: CCDS42479.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001080452.1
exon count: 18CDS single in 3' UTR: no RNA size: 2076
ORF size: 1632CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3379.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.