Human Gene SLTM (uc002afp.3) Description and Page Index
Description: Homo sapiens SAFB-like, transcription modulator (SLTM), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr15:59,171,244-59,225,852 Size: 54,609 Total Exon Count: 21 Strand: -
Position: hg19 chr15:59,172,198-59,225,764 Size: 53,567 Coding Exon Count: 21
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=SAFB-like transcription modulator; AltName: Full=Modulator of estrogen-induced transcription;
FUNCTION: When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Detected in punctate structures (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SIMILARITY: Contains 1 SAP domain. SEQUENCE CAUTION: Sequence=AAI08657.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB14502.1; Type=Erroneous initiation; Sequence=BAB14971.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
SLTM CDC HuGE Published Literature:
SLTM Positive Disease Associations: Asperger Syndrome
Asperger Syndrome D Salyakina et al. Autism research 2010, Variants in several genomic regions associated with asperger disorder., Autism research : official journal of the International Society for Autism Research.
Insulin , , .
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom
IPR003034 - SAP_DNA-bd
Pfam Domains: PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF02037 - SAP domain
PF13893 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SCOP Domains: 68906 - SAP domain
54928 - RNA-binding domain, RBD
ModBase Predicted Comparative 3D Structure on Q9NWH9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC046119 - Homo sapiens SAFB-like, transcription modulator, mRNA (cDNA clone IMAGE:6196843), partial cds. AK023275 - Homo sapiens cDNA FLJ13213 fis, clone NT2RP4001126, weakly similar to TRICHOHYALIN. JD344589 - Sequence 325613 from Patent EP1572962. JD386243 - Sequence 367267 from Patent EP1572962. JD206526 - Sequence 187550 from Patent EP1572962. JD562388 - Sequence 543412 from Patent EP1572962. JD185895 - Sequence 166919 from Patent EP1572962. JD359359 - Sequence 340383 from Patent EP1572962. BC040120 - Homo sapiens SAFB-like, transcription modulator, mRNA (cDNA clone IMAGE:5110622), with apparent retained intron. AK055195 - Homo sapiens cDNA FLJ30633 fis, clone CTONG2002418, highly similar to Homo sapiens modulator of estrogen induced transcription, transcript variant 1, mRNA. AL834297 - Homo sapiens mRNA; cDNA DKFZp762G052 (from clone DKFZp762G052). BC014944 - Homo sapiens SAFB-like, transcription modulator, mRNA (cDNA clone IMAGE:4864860), partial cds. JD113045 - Sequence 94069 from Patent EP1572962. JD147430 - Sequence 128454 from Patent EP1572962. AK291423 - Homo sapiens cDNA FLJ78261 complete cds. JD513869 - Sequence 494893 from Patent EP1572962. JD563023 - Sequence 544047 from Patent EP1572962. JD180377 - Sequence 161401 from Patent EP1572962. BC140851 - Homo sapiens SAFB-like, transcription modulator, mRNA (cDNA clone MGC:176528 IMAGE:9021719), complete cds. JD553082 - Sequence 534106 from Patent EP1572962. JD305202 - Sequence 286226 from Patent EP1572962. JD173367 - Sequence 154391 from Patent EP1572962. JD180557 - Sequence 161581 from Patent EP1572962. AK024710 - Homo sapiens cDNA: FLJ21057 fis, clone CAS00705. AK000867 - Homo sapiens cDNA FLJ10005 fis, clone HEMBA1000156. AK131242 - Homo sapiens cDNA FLJ16159 fis, clone BRCAN2002854. BC108656 - Homo sapiens SAFB-like, transcription modulator, mRNA (cDNA clone IMAGE:4520738), partial cds.
Other Names for This Gene
Alternate Gene Symbols: B2RTX3, MET, NM_024755, NP_079031, Q2VPK7, Q52MB3, Q658J7, Q6ZNF2, Q86TK6, Q9H7C3, Q9H8U9, Q9NWH9, SLTM_HUMAN UCSC ID: uc002afp.3 RefSeq Accession: NM_024755
(aka SLTM_HUMAN) Q9NWH9
Gene Model Information
21 CDS single in 3' UTR:
3105 CDS single in intron:
Alignment % ID:
6333.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.