Human Gene SART1 (uc001ogl.3) Description and Page Index
Description: Homo sapiens squamous cell carcinoma antigen recognized by T cells (SART1), mRNA. RefSeq Summary (NM_005146): This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.130432.1, SRR1660807.226377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000312397.10/ ENSP00000310448.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr11:65,729,160-65,747,607 Size: 18,448 Total Exon Count: 20 Strand: + Coding Region Position: hg19 chr11:65,729,252-65,746,501 Size: 17,250 Coding Exon Count: 20
ID:SNUT1_HUMAN DESCRIPTION: RecName: Full=U4/U6.U5 tri-snRNP-associated protein 1; AltName: Full=SNU66 homolog; Short=hSnu66; AltName: Full=Squamous cell carcinoma antigen recognized by T-cells 1; Short=SART-1; Short=hSART-1; AltName: Full=U4/U6.U5 tri-snRNP-associated 110 kDa protein; AltName: Allergen=Hom s 1; FUNCTION: May play a role in mRNA splicing. May also bind to DNA. SUBUNIT: Identified in the spliceosome C complex. Part of a tri- snRNP complex. INTERACTION: P63165:SUMO1; NbExp=2; IntAct=EBI-607761, EBI-80140; P55854:SUMO3; NbExp=2; IntAct=EBI-607761, EBI-474067; SUBCELLULAR LOCATION: Nucleus. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells. TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Sumoylated with SUMO2. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. ALLERGEN: Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations. SIMILARITY: Belongs to the SNU66/SART1 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SART1 CDC HuGE Published Literature: SART1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43290
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.