ID:EXOSX_HUMAN DESCRIPTION: RecName: Full=Exosome component 10; EC=3.1.13.-; AltName: Full=Autoantigen PM/Scl 2; AltName: Full=P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; AltName: Full=Polymyositis/scleroderma autoantigen 100 kDa; Short=PM/Scl-100; AltName: Full=Polymyositis/scleroderma autoantigen 2; FUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. SUBUNIT: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Interacts with C1D and MPHOSPH6. INTERACTION: Q13901:C1D; NbExp=5; IntAct=EBI-358236, EBI-3844053; Q99547:MPHOSPH6; NbExp=4; IntAct=EBI-358236, EBI-373187; SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. SIMILARITY: Contains 1 3'-5' exonuclease domain. SIMILARITY: Contains 1 HRDC domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01780
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000460 maturation of 5.8S rRNA GO:0000956 nuclear-transcribed mRNA catabolic process GO:0006139 nucleobase-containing compound metabolic process GO:0006364 rRNA processing GO:0006396 RNA processing GO:0009048 dosage compensation by inactivation of X chromosome GO:0032211 negative regulation of telomere maintenance via telomerase GO:0044237 cellular metabolic process GO:0071028 nuclear mRNA surveillance GO:0071034 CUT catabolic process GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process GO:0071044 histone mRNA catabolic process GO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic GO:1904872 regulation of telomerase RNA localization to Cajal body
US Server
