Human Gene NOC2L (uc001abz.4) Description and Page Index
  Description: Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae) (NOC2L), mRNA.
RefSeq Summary (NM_015658): Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225239.1, AK024284.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327044.7/ ENSP00000317992.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr1:879,583-894,679 Size: 15,097 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg19 chr1:880,074-894,620 Size: 14,547 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:879,583-894,679)mRNA (may differ from genome)Protein (749 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Nucleolar complex protein 2 homolog; Short=Protein NOC2 homolog; AltName: Full=NOC2-like protein; AltName: Full=Novel INHAT repressor;
FUNCTION: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
SUBUNIT: Interacts with p53/TP53. Interacts (via the N- and C- terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes.
INTERACTION: O15265:ATXN7; NbExp=2; IntAct=EBI-751547, EBI-708350; P04637:TP53; NbExp=8; IntAct=EBI-751547, EBI-366083;
SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin- D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
INDUCTION: Up-regulated by IL4 and CD40L in B-cells.
SIMILARITY: Belongs to the NOC2 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: NOC2L
Diseases sorted by gene-association score: corneal dystrophy, posterior amorphous (2), retinitis pigmentosa, y-linked (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.24 RPKM in Testis
Total median expression: 1231.11 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.5059-0.398 Picture PostScript Text
3' UTR -216.30491-0.441 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR005343 - UPF0120

Pfam Domains:
PF03715 - Noc2p family

ModBase Predicted Comparative 3D Structure on Q9Y3T9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologGenome Browser
Gene Details  Gene Details Gene Details
Gene Sorter  Gene Sorter Gene Sorter
  EnsemblFlyBase SGD
  Protein SequenceProtein Sequence Protein Sequence
  AlignmentAlignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0042393 histone binding
GO:0070491 repressing transcription factor binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002903 negative regulation of B cell apoptotic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0031497 chromatin assembly
GO:0034644 cellular response to UV
GO:0035067 negative regulation of histone acetylation
GO:0042273 ribosomal large subunit biogenesis
GO:1901796 regulation of signal transduction by p53 class mediator
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0030690 Noc1p-Noc2p complex
GO:0030691 Noc2p-Noc3p complex

-  Descriptions from all associated GenBank mRNAs
  AF161376 - Homo sapiens HSPC258 mRNA, partial cds.
AK225239 - Homo sapiens mRNA for Nucleolar complex protein 2 homolog, clone: COL07101.
AK092491 - Homo sapiens cDNA FLJ35172 fis, clone PLACE6013232.
AX747569 - Sequence 1094 from Patent EP1308459.
AK022756 - Homo sapiens cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186).
AK024284 - Homo sapiens cDNA FLJ14222 fis, clone NT2RP3003992, highly similar to Nucleolar complex protein 2 homolog.
AL050019 - Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186).
BC003555 - Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae), mRNA (cDNA clone MGC:1451 IMAGE:3546209), complete cds.
JD451658 - Sequence 432682 from Patent EP1572962.
JD493513 - Sequence 474537 from Patent EP1572962.
JD393947 - Sequence 374971 from Patent EP1572962.
JD252686 - Sequence 233710 from Patent EP1572962.
JD079681 - Sequence 60705 from Patent EP1572962.
JD198987 - Sequence 180011 from Patent EP1572962.
JD223744 - Sequence 204768 from Patent EP1572962.
JD454297 - Sequence 435321 from Patent EP1572962.
JD353504 - Sequence 334528 from Patent EP1572962.
AK315080 - Homo sapiens cDNA, FLJ96036.
KJ898602 - Synthetic construct Homo sapiens clone ccsbBroadEn_07996 NOC2L gene, encodes complete protein.
AB463150 - Synthetic construct DNA, clone: pF1KB8582, Homo sapiens NOC2L gene for nucleolar complex associated 2 homolog, without stop codon, in Flexi system.
AM393843 - Synthetic construct Homo sapiens clone IMAGE:100001909 for hypothetical protein (NOC2L gene).
CU678496 - Synthetic construct Homo sapiens gateway clone IMAGE:100020056 5' read NOC2L mRNA.
BC009786 - Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4274902), with apparent retained intron.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y3T9 (Reactome details) participates in the following event(s):

R-HSA-3222128 NOC2L binds TP53
R-HSA-6805122 AURKB binds TP53
R-HSA-6805126 AURKB phosphorylates TP53
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NIR, NM_015658, NOC2L_HUMAN, NP_056473, Q5SVA3, Q9BTN6, Q9Y3T9
UCSC ID: uc001abz.4
RefSeq Accession: NM_015658
Protein: Q9Y3T9 (aka NOC2L_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_015658.3
exon count: 19CDS single in 3' UTR: no RNA size: 2817
ORF size: 2250CDS single in intron: no Alignment % ID: 99.93
txCdsPredict score: 4480.00frame shift in genome: no % Coverage: 99.40
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.